MOLECULAR BIOLOGY OF VARICELLA ZOSTER VIRUS INFECTION

水痘-带状疱疹病毒(VZV)的初次感染会导致水痘， 而从潜伏期重新激活病毒会导致带状疱疹。目标 该项目的主要目的是鉴定和确定VZV基因的功能 在潜伏期内表达，并开发新的动物模型来 研究急性和潜伏感染。 两只接种VZV的黑猩猩在10天内出现丘疹 接种后。在两人的白细胞中均检测到VZV DNA 动物接种后不久，在皮肤活检中从其中一个 皮疹发生时的动物。 研究VZV基因(ORF21)的其他实验正在进行中 据报道，在动物的潜伏期内表达。这项规定 将对VZV ORF21基因的表达进行分析，并对该基因的表达 将研究动物模型和人类的基因。

Primary infection with varicella-zoster virus (VZV) causes chickenpox, and reactivation of the virus from latency results in zoster. The goals of this project are to identify and determine the function of VZV genes that are expressed during latency and to develop new animal models to study acute and latent infection. Two chimpanzees inoculated with VZV developed a papular rash ten days after inoculation. VZV DNA was detected in white blood cells of both animals shortly after inoculation and in a skin biopsy from one of the animals at the time of the rash. Additional experiments are underway to study a VZV gene (ORF21) that has been reported to be expressed during latency in animals. The regulation of VZV ORF21 gene expression will be analyzed and expression of this gene in animal models and in humans will be studied.