AGE CHANGES IN PULMONARY FUNCTION

工作总结：BLSA在肺老化方面的计划侧重于： 健康、不吸烟和健康男性FEV1纵向变化的研究 据报道，有女性。对FEV1变化的纵向分析为 对91名男性和82名女性进行了调查，这些人没有呼吸系统病史 他有很多问题，而且从不吸烟。对FEV1数据进行建模 使用混合效应回归模型和纵向百分位数 建立了FEV1水平的分布。调查结果显示：1) FEV1的平均纵向下降率约为240-340 男性和女性的毫升/十年，2)参与者中没有一人表现出 FEV1的持续改善，以及3)受试者之间的变异性是 男性大于女性，男性随着年龄增长而增加，但减少 随着女性年龄的增长。按年龄和性别划分的百分位数分布 是第一个反映变异性年龄差异的诺模图 在肺功能方面。 最大吸气压(MIP)的年龄相关性变化。十字 对400名男性和295名女性的数据进行了横断面分析 年龄在20岁到90岁之间。女性的平均MIP 不同年龄段的人大约是男性的三分之二。参考 在一个健康的子集上建立了MIP方程。

Summary of Work: The BLSA Program in Pulmonary Aging has focused on: A study of longitudinal changes in FEV1 in healthy, non-smoking men and women was reported. Longitudinal analyses of changes in FEV1 were conducted among 91 men and 82 women who had no history of respiratory problems and had never smoked cigarettes. The FEV1 data were modeled using a mixed-effects regression model and longitudinal percentile distributions of FEV1 level were constructed. The findings showed 1) the average longitudinal rate of decline in FEV1 was approximately 240-340 ml/decade in men and women, 2) none of the participants exhibited a sustained improvement in FEV1, and 3) between-subjects variability is greater in men than women and increases with age in men, but decreases with age in women. The age- and gender-specific percentile distributions are the first nomograms which reflect age differences in the variability in pulmonary function. Age associated changes in Maximal Inspiratory Pressure (MIP). Cross sectional analyses of data consisting of 400 men and 295 women ranging in age between 20 and 90 years were done. The average MIP of females across the different age groups was about two thirds that of men. Reference equations for MIP in a healthy subset have been constructed.