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STRUCTURAL STUDIES OF BRCT RECOGNITION OF PHOSPHOPROTEINS

STRUCTURAL STUDIES OF BRCT RECOGNITION OF PHOSPHOPROTEINS
BRCT 磷酸蛋白识别的结构研究
批准号:
7369493
负责人:
NIKOLA P PAVLETICH
金额:
$0.18万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-06-01 至 2007-05-31

项目摘要

项目成果

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中文摘要
翻译
该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者(PI)可能从另一个NIH来源获得主要资金,因此可以在其他CRISP条目中表示。所列机构为中心机构,不一定为研究者机构。Brca 2被认为是同源重组途径中的关键组分。我们已经展示了Brca 2的C-末端如何与单链DNA结合。为了了解其生理功能,我们希望确定Brca 2蛋白及其识别底物和相互作用伙伴(包括rad 51)的结构。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Brca2 is believed to be a critical component in homologous recombination pathway. We have shown how th c-terminal of Brca2 binds with single strand DNA. In order to understand its physiological function, we would like to determine structure of Brca2 protein with its recognized substrate and interacting partners, including rad51.
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Structural Mechanisms of DNA Damage Sensing and Activation of the ATR, Fanconi Anemia, and ATM Checkpoints
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    10639156
  • 项目类别:
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  • 财政年份:
    2023
  • 负责人:
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STRUCTURAL STUDIES OF DNA REPAIR PROTEINS
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    2011
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  • 项目类别:
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  • 财政年份:
    2010
  • 负责人:
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海外基金