500 MHz NMR Spectrometer to Support Organic, Bio-organic and Inorganic Chemistry

核磁共振波谱是阐明化学结构的重要工具。一群对有机化学、生物有机化学和无机化学感兴趣的合成化学家需要一种新的核磁共振波谱仪，其工作磁场(500 MHz)比目前可用的更高。这台光谱仪将促进巴斯化学系的新研究领域，因为它提供了以下核磁共振设施：(A)高灵敏度(将提供比目前的400 MHz核磁共振仪增加40%左右的区域)，(B)更高的分辨率，将能够从更复杂的分子中分离出共振，(C)新的硬件(例如，可以研究较低频率的原子核，而反向探测探测器将提供更高的质子灵敏度，允许对仅有很少量可用的化合物进行表征和建立其结构)。能够实现的具体领域包括手性分子的合成、多肽和蛋白质的修饰以及新催化剂的开发。

NMR spectroscopy is a key tool in the elucidation of chemical structure. A new NMR spectrometer operating at higher field (500 MHz) than currently available is required by a group of synthetic chemists interested in organic, bio-organic and inorganic chemistry. This spectrometer will facilitate new research areas in the Department of Chemistry at Bath by providing access to NMR facilities with (a) high sensitivity (somewhere in the region of a 40% increase over our current 400 MHz NMR spectrometer will be provided), (b) greater resolution that will allow resonances from more complex molecules to be separated out and (c) new hardware (for example, lower frequency nuclei can be studied, while an inverse detection probe will give higher proton sensitivity, allowing compounds only available in very small amounts to be characterised and and their structures established). Specific areas that will be enabled include the synthesis of chiral molecules, modification of peptides and proteins and the development of new catalysts.