Core Center for Quantitative Neuroscience with magnetic Resonance (QNMR)

磁共振(MR)技术在生命科学研究中的应用正在迅速增长。 最新的异核磁共振波谱(MRS)和多模式磁共振成像(MRI)方法 在耶鲁大学磁共振研究中心培养的动物体内活动 研究实验神经科学的核心作用，解决具有深远影响的基本问题 对大脑功能的影响。自20世纪80年代初耶鲁大学MRRC成立以来， 用于活体研究的水平孔磁铁在2004年增加了三倍。目前的数字为‘ 需要用于活体研究的磁铁--动物和人类各三个--以适应日益增长的 许多学科的调查人员数量--其中大部分得到了NINDS的支持。这个 耶鲁大学MRRC的优势过去是，现在仍然是，啮齿动物和人类之间的动态互动 研究。啮齿类动物异核磁共振波谱与多模式磁共振成像方法的主动相互作用 此外，人类进步很快。因为MR技术需要坚定不移的基础设施 支持最先进的漏洞被成功应用，耶鲁MRRC的长期稳定性是 这取决于持续的支持。《磁共振定量神经科学》项目 (QNMR)“将支持NINDS资助的研究人员在耶鲁使用的共享资源和设施， 从而产生比独立努力可能产生的更大的生产力。Q核磁共振将包括 三个研究核心-每个核心致力于提高基于多模式的正在进行的研究的有效性 MRI、异核MRS、神经生理学和一个服务核心-专为快速数据而设计 使用高性能的工作站群集进行分析、访问、共享和备份。我们期待着 Q核磁共振将为神经科学家提供一个更具合作性和互动性的研究环境 利用耶鲁大学的磁共振技术，并将在医学、生理学、 和神经科学。

Applications of magnetic resonance (MR) techniques to research in the life sciences are growing rapidly. State-of-the-art heteronuclear MR spectroscopy (MRS) and multi-modal MR imaging (MRI) methodologies cultivated at the Magnetic Resonance Research Center (MRRC) at Yale have moved in vivo animal research into central roles in experimental neuroscience, addressing fundamental issues with far reaching implications for brain function. Since the formation of the Yale MRRC in the early in 1980s, the number of . horizontal-bore magnets for in vivo studies have multiplied three-fold in 2004. The present number of ' magnets for in vivo studies - three each for animals and humans - were needed to match the growing number of investigators across many disciplines - a majority of whom are supported by NINDS. The strength of the Yale MRRC has been, and still is, the dynamic interaction between rodent and human research. Active interplay between heteronuclear MRS and multi-modal MRI methods in rodents and humans have furthermore rapidly progressed. Because MR technology requires unwavering infrastructural support for state-of-the-art exploits to be successfully applied, long-term stability of Yale MRRC is contingent on sustained support. A program in "Quantitative Neuroscience with Magnetic Resonance (QNMR)" at Yale will support shared resources and facilities used by NINDS-funded investigators at Yale, and thereby generate greater productivity than would be possible via independent efforts. QNMR will consist of three research Cores - each dedicated to improving effectiveness of ongoing research based upon multimodal MRI, heteronuclear MRS, neurophysiology - and one service Core - designed for rapid data analysis, access, sharing, and backup using high-performance cluster of workstations. We expect that QNMR will promote a more cooperative and interactive research environment for neuroscientists who are utilizing MR technology at Yale, and will nurture new cross-disciplinary approaches in medicine, physiology, and neuroscience.