Chemistry-Biology Interface Training Grant

描述(申请人提供)：这是化学-生物界面(CBI)培训资助T32 GM08804的第一次续签。我们设计了一个跨学科的计划，在生物、药物和传统化学的界面上培训学生(和教师)，称为生物化学计划(BCP)。该项目始于2000年秋季，为对生物化学感兴趣的学生提供有重点的、跨学科的教育。该计划完全融入了三个参与的系，学生可以在完成生物化学培训计划的同时获得化学、生物化学和分子生物物理学或药理学和毒理学(药物化学系)的学位。学生承担所有三个系的课程工作，在至少两个系轮流进行研究，并参加每周一次的BCP研究论坛，学生和教职员工在论坛上展示研究成果。重要的是，学生可以与项目中的任何人合作，而不考虑系属关系，从而允许真正的多学科研究努力。培训人员包括来自四个系的34个高度活跃的研究小组。学生在BCP中一直保持活跃状态，直到毕业。目前有36名学生参加了培训计划，其中21人符合培训补助金条件；预计秋季还会有6-10名学生加入。自2000年开办以来，已有8名学生完成了该项目，获得了博士学位。培训补助金的时间通常为第二年和第三年，这使得培训补助金获得者在组合多学科研究项目时具有很大的灵活性。奖学金在学生第二学期接近结束时颁发，在他们选择论文导师之前，帮助他们组建一个基础广泛的团队。在6-10学年，我们要求每年提供8个培训助学金名额，允许每年授予4个2年期奖学金，并在任何给定时间资助约1/3符合培训助学金资格的学生。化学-生物学接口的培训与公共卫生的进步密切相关。许多最重要的发现发生在一个或多个学科的交叉点上，其中一个领域的知识被运用到另一个领域的问题上。通过将化学、药物化学和生物化学相结合，我们的学员将在药物发现、疾病检测、疾病预防和发现疾病的根本原因方面取得下一步突破。

DESCRIPTION (provided by applicant): This is the first renewal of Chemistry-Biology Interface (CBI) training grant T32 GM08804. We have designed an interdisciplinary program for training students (and faculty) at the interface of biological, medicinal, and traditional chemistry, called the Biological Chemistry Program (BCP). This program, which began in the fall of 2000, provides a focused, cross-disciplinary education for students interested in biological chemistry. The program is fully integrated into the three participating departments and students may obtain a degree in Chemistry, Biochemistry and Molecular Biophysics, or Pharmacology and Toxicology (Medicinal Chemistry Division) while following the Biological Chemistry Training Program. Students undertake coursework in all three departments, perform research rotations in at least two departments and participate in the weekly BCP research forum, where students and faculty present research results. Importantly, students may work with anyone in the program, regardless of departmental affiliation, allowing for true multi- disciplinary research efforts. The training faculty includes 34 highly-active research groups from four departments. Students remain active in the BCP until graduation. There are 36 students currently following the training program, 21 of which are training grant eligible; an additional 6-10 students are expected to join in the fall. Since inception in 2000, 8 students have completed the program with a PH.D. degree. Training grant slots are generally made for years 2 and 3 in the program, allowing training grant recipients great flexibility in assembling a multi-disciplinary research project. Fellowships are awarded near the end of the student's second semester, before they choose a thesis advisor, to assist in assembling a broad-based team. For years 6-10, we request 8 training grant slots per year, allowing for four 2-year fellowships to be awarded per year, and ~1/3 of our training-grant-eligible students to be funded at any given time. Training at the Chemistry-Biology Interface is highly relevant for advances in public health. Many of the most important discoveries occur at the intersection of one or more disciplines, where the knowledge of one field is brought to bear on the problems of another. By blending Chemistry, Medicinal Chemistry and Biochemistry, our trainees are poised to make the next breakthroughs in drug discovery, disease detection, disease prevention, and the discovery of the underlying causes of disease.