Pediatric Center for Gene Expression and Development

此申请是为了继续资助我们的儿童健康研究职业发展奖 （CHRCDA），它建立了一个独特的卓越中心，以加强基础和临床 儿科研究培训，重点是分子和细胞生物学以及临床科学。这是 这是第三次更新。我们的CHRCDA支持了我们机构的32名学者，其中许多人 成为儿科学术界的全国领导者我们的学者共发表了约644篇论文， 获得了超过5000万美元的赠款资金（包括28个R 01）。该中心提高学术 年轻儿科教师的职业发展，提供指导和核心设施，旨在提高 对儿科医生进行学术生涯所需的培训。该中心是一个创新的 建立了研究培训计划，包括Procter Scholar计划和NIH资助的广泛项目 研究项目。该计划确定并招募有前途的年轻儿科教师谁完成2- 3年计划，在CHRCDA计划内加强研究，由高级科学家导师组成 他们共同关注分子细胞生物学、分子医学或临床科学。职业生涯 发展包括：1）中心工作人员调查员的个人指导; 2）正式和非正式培训 分子遗传学、发育生物学、临床研究、流行病学和转化研究; 和3）核心研究要素，优先考虑不同研究方法的培训，包括分子生物学 生物学、免疫学、基因组学和转基因/基因靶向模型。目前的建议已提请 在儿童医院一起建立了在发展科学方面具有卓越成就的研究人员， 辛辛那提大学医学院。为了实现pur培训目标，提出了一个由四部分组成的中心： 1)中心工作人员研究者在分子和细胞生物学的应用方面具有共同的兴趣和专业知识， 生物学和信息技术在哺乳动物发育，分子医学和临床研究中的应用 研究是儿科医生学者的主要导师。2)行政核心确定征聘人员 并监督儿科学者的整体培训。核心小组为国家征聘提供支助 在地方和国家一级作出努力，并优先考虑招募少数群体。3)研究核心促进了 应用分子和细胞生物学、临床研究/流行病学和统计学进行研究 儿科学者项目。4)研究支持赠款提供儿科医生学者研究 资金和指导为期2-3年。这种个人指导和 当代分子、细胞、发育生物学和临床科学的高级培训 提高我们的物理学者的培训和研究生产力，因为他们开始高生产力 儿科科学的学术生涯。

This application is for continued funding for our Child Health Research Career Development Award (CHRCDA), which has established a unique center of excellence for the enhancement of basic and clinical research training in pediatrics with focus on molecular and cellular biology and clinical sciences. This is the third renewal of this grant. Our CHRCDA has supported 32 scholars at our institution, many of whom have become national leaders in academic pediatrics. Collectively, our scholars have published ~644 papers and obtained over $50 million in grant dollars of funding (including 28 R01's). The Center enhances academic career development of young pediatric faculty, providing mentorship and Core facilities designed to enhance the training of pediatricians as required for an academic career. The Center is integrated into innovative established programs for research trainmg including the Procter Scholar Program and extensive NIH funded research programs. The program identifies and recruits promising young pediatric faculty who complete a 2- 3 year program for research enhancement within a CHRCDA program comprised of senior scientist mentors who share a central focus in molecular-cellular biology, molecular medicine or clinical sciences. Career development includes: 1) individual mentorship by Center staff investigators; 2) formal and informal training in molecular genetics, developmental biology, clinical research, epidemiology, and translational research; and 3) Core research elements which prioritizes training in diverse research approaches including molecular biology, immunology, genomics and transgenic/gene targeting models. The present proposal has drawn together established investigators with exceljence in developmental science at the Children's Hospital and the University of Cincinnati College of Medicine. To meet pur training goals, a four-part Center is proposed: 1) Center staff investigators who share interest and expertise in the application of molecular and cellular biology and informatics technology in the study of mammalian development, molecular medicine, and clinical research serve as primary mentors for the pediatrician-scholars. 2) Administrative Core identifies recruits and monitors the overall training of pediatrician-scholars. The Core provides support for national recruitment efforts, at local and national levels and prioritizes minority recruitment. 3) Research Cores facilitate the application of molecular and cellular biology, clinical research/epidemiology and statistics to the research programs of pediatrician-scholars. 4) Research support grants provide the pediatrician-scholar research funds and mentorship for a period of 2-3 years. This combined program of individual mentorship and advanced training in contemporary molecular, cellular, developmental biology, and clinical sciences enhances the training and research productivity of our physian-scholars as they begin highly productive academic careers in pediatric science.