AMINO ACID SUPPPLEMENTATION AND MUSCLE

肌肉萎缩和无力在被迫不活动和卧床后普遍存在。不幸的是，卧床是重大骨科手术、严重损伤或长期疾病后恢复的一个固有方面。缺乏运动导致瘦体质量（LBM）的固有损失与恢复时间增加和发病率增加有关。由于大型骨科手术和严重疾病的更大流行，老年人在与这些压力相结合的情况下，与长时间的被迫不活动相关的发病率和死亡率风险增加。我们之前对年轻人的研究表明，最小阻力运动和营养补充必需氨基酸（EAA）可以维持LBM，保持或减少肌肉功能的丧失。因此，本项目的目标是研究EAA单独或与阻力或步行运动联合对老年人肌肉蛋白质代谢、LBM和肌肉功能的影响。我们建议研究三组老年男性和女性（65-80岁）在卧床10天之前，期间和之后：1)每天单独补充三次EAA的组（EAA）， 2)在卧床期间补充同样的EAA并进行三次阻力运动的组（EAA+RE），以及3)补充EAA并进行标准护理每日步行运动的组（EAA+ We）。UAMS的Trappe博士将单独测试RE和WE的影响；然而，我们将检验EAA和这些运动方案相结合在保持肌肉蛋白质合成、LBM和肌肉功能方面比单独干预更有效的假设。此外，我们建议这些干预措施的组合将加速从卧床恢复。最后，我们建议这些干预措施或干预措施的组合将有效地维持老年人的肌肉蛋白质合成，肌肉质量和功能。

Muscle wasting and weakness are prevalent after forced inactivity and bedrest. Unfortunately, bedrest is an inherent aspect of recovery from major orthopedic surgery, serious injury, or prolonged illness. The inherent loss of lean body mass (LBM) with inactivity is associated with increased recovery time and increased morbidity. Due to the greater prevalence of major orthopedic operations and serious illness, older individuals are at an increased risk for morbidity and mortality associated with extended periods of forced inactivity when combined with these stresses. Our previous investigations in younger individuals demonstrated that minimal resistance exercise and nutritional supplementation with essential amino acids (EAA) can maintain LBM and preserve or diminish the loss of muscle function. Therefore, the goal of this project is to examine the effects of EAA alone or in combination with resistance or walking exercise on muscle protein metabolism, LBM, and muscle function in older individuals. We propose to study three groups of older men and women (65-80 years) before, during, and after 10 days of bedrest: 1) a group who will receive three supplements per day of EAA alone (EAA), 2) a group that will receive the same EAA supplementation plus three sessions of resistance exercise throughout bedrest (EAA+RE), and 3) a group who will receive EAA supplementation plus the standard-of-care daily walking exercise (EAA+WE). The effects of RE and WE alone will be tested by Dr. Trappe at UAMS; however, we will examine the hypotheses that the combination of EAA and these exercise regimens will be more effective in preserving muscle protein synthesis, LBM, and muscle function than either intervention alone. Further, we propose that combination of these interventions will expedite recovery from bedrest. Finally, we propose that these interventions, or combination of interventions, will be effective in maintaining muscle protein synthesis, muscle mass, and function in the elderly.