Fish oil and neurovascular control in humans

描述（由申请人提供）：本提案的主要目的是研究鱼油（omega-3脂肪酸）对人类神经血管控制的影响。具体来说，本项目将研究鱼油对：1)正常血压和高血压个体的静息血压和肌肉交感神经活动（MSNA）的影响，以及2)正常血压和高血压个体对精神压力的神经血管反应。本项目的具体目标是：1。测定鱼油对人体静息时血压和微细核糖核酸的影响。在8周的鱼油补充期前后将测量静息血压和MSNA。将对正常血压和高血压受试者进行研究。据推测，鱼油可以降低高血压患者的血压，而血压的降低与静息时MSNA的降低有关。2. 目的：确定鱼油对血压和心理应激时MSNA反应的影响。在八周的鱼油补充期前后，将直接测量腓神经对精神压力的MSNA反应。将对正常血压和高血压受试者进行研究。假设鱼油可以抑制高血压患者的血压和MSNA对精神应激的反应。3. 确定鱼油对前臂和小腿血管对精神压力反应的影响。在8周的鱼油补充前后，使用静脉闭塞容积描记术同时记录前臂和小腿对精神压力的血流反应。将对正常血压和高血压受试者进行研究。假设鱼油会增强前臂血管舒张对精神压力的反应，并且这种反应在高血压患者中更为明显。4. 目的：探讨鱼油对精神压力下交感神经和血管恢复反应的影响。在八周的鱼油补充期前后，将测量精神压力后的血压、MSNA和血流量。将对正常血压和高血压受试者进行研究。据推测，鱼油会减少精神压力后血压、MSNA和血流量恢复到基线水平所需的时间。鱼油可以降低心血管疾病的发病率，但这种关系背后的机制尚不清楚。该项目将提供关于鱼油对正常和高血压人类神经血管控制作用的新知识。

DESCRIPTION (provided by applicant): The broad objective of this proposal is to examine the influence of fish oil (omega-3 fatty acids) on neurovascular control in humans. Specifically, this project will examine the effect of fish oil on: 1) resting blood pressure and muscle sympathetic nerve activity (MSNA) in normotensive and hypertensive individuals, and 2) neurovascular responses to mental stress in normotensive and hypertensive individuals. The specific aims of this project are: 1. To determine the effect of fish oil on blood pressure and MSNA at rest in humans. Resting blood pressure and MSNA will be measured before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will reduce blood pressure in hypertensive subjects, and that reductions in blood pressure will be associated with reductions in resting MSNA. 2. To determine the effect of fish oil on blood pressure and MSNA responses to mental stress. MSNA responses to mental stress will be measured directly from the peroneal nerve before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will inhibit blood pressure and MSNA responses to mental stress in hypertensive subjects. 3. To determine the effect of fish oil on forearm and calf vascular responses to mental stress. Forearm and calf blood flow responses to mental stress will be simultaneously recorded using venous occlusion plethysmography before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will enhance the forearm vasodilation response to mental stress, and that this response will be more dramatic in hypertensive subjects. 4. To determine the effect of fish oil on sympathetic and vascular recovery responses to mental stress. Post mental-stress blood pressure, MSNA and blood flow will be measured before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will reduce the amount of time required to return blood pressure, MSNA, and blood flow to baseline conditions after mental stress. Fish oil reduces the incidence of cardiovascular disease, but the mechanisms underlying this relationship remain unclear. This project will provide new knowledge regarding the effect of fish oil on neurovascular control in both normotensive and hypertensive humans.