Alcohol and Neurovascular Control in Humans

酒精与人类神经血管控制

• 批准号: 10074696
• 负责人: Jason R Carter
• 金额: $ 31.36万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10074696
• 关键词: Alcohol; Neurovascular; Control; Humans

Project Summary There is wide-spread recognition that `binge' alcohol consumption is associated with increased cardiovascular risk, but much of this is based on epidemiological studies and mechanisms remain poorly understood. Sympathetic overactivity has been suggested as a potential mechanism for alcohol-mediated cardiovascular disease, but direct evidence is lacking. The proposed project represents our first step in the pursuit of a long- term goal to explore alcohol-mediated hypertension, stroke, and sudden cardiac death, and practical interventions that might reduce the incidence of these cardiovascular conditions. The proposed project focuses on the impact of evening alcohol consumption on nocturnal and early morning autonomic function and reactivity in male and female binge drinkers. In aim 1, will determine the effect of evening alcohol consumption on nocturnal autonomic control and sympathetic neural responsiveness the subsequent morning. Aim 2 will determine the influence of sex (male vs. female) and the ovarian cycle (early follicular vs. midluteal phase) on sympathetic neural responsiveness to evening alcohol in humans. Aim 3 will determine if continuous positive airway pressure (CPAP) blunts alcohol-mediated sympathoexcitation at night and early morning. An exploratory aim will determine if autonomic responses to alcohol and CPAP are associated with affective states and psychomotor performance. Our central hypothesis is that evening alcohol consumption will elicit sympathetic overactivity at night and the subsequent morning, and that this sympathoexcitation will be augmented women and blunted after CPAP treatment. The novelty and innovation of this project is that our mechanistic aims are bolstered with an interventional aim that includes a randomized, control trial (CPAP vs. sham-CPAP). The project utilizes established, gold-standard methods for assessing sleep (polysomnography) and sympathetic neural activity and reactivity (microneurography). In summary, this project will determine the impact of simulated `binge' alcohol consumption on neural cardiovascular function at times of elevated cardiovascular risk (i.e., sleep and early morning) in male and female binge drinkers, and test a potential therapeutic strategy (i.e., CPAP) to blunt alcohol-induced autonomic dysfunction.

项目概要 人们普遍认为“暴饮暴食”饮酒与心血管疾病增加有关 风险，但其中大部分基于流行病学研究，且机制仍知之甚少。 交感神经过度活跃被认为是酒精介导的心血管疾病的潜在机制 病，但缺乏直接证据。拟议的项目是我们追求长期目标的第一步 探索酒精介导的高血压、中风和心源性猝死的学期目标以及实践 可能减少这些心血管疾病发生率的干预措施。拟议项目重点 晚上饮酒对夜间和清晨自主神经功能的影响 男性和女性酗酒者的反应性。在目标 1 中，将确定晚上饮酒的影响 夜间自主控制和第二天早上交感神经反应性。目标2将 确定性别（男性与女性）和卵巢周期（卵泡早期与黄体中期）对 人类交感神经对夜间酒精的反应。目标 3 将确定是否连续积极 气道压力（CPAP）会在夜间和清晨减弱酒精介导的交感神经兴奋。一个 探索性目标将确定对酒精和 CPAP 的自主反应是否与情感状态相关 和精神运动表现。我们的中心假设是晚上饮酒会引起 交感神经在晚上和第二天早上过度活跃，并且这种交感神经兴奋将 女性在 CPAP 治疗后会增强并减弱。这个项目的新颖性和创新之处在于我们 机械目标得到干预目标的支持，其中包括随机对照试验（CPAP 与呼吸机治疗）。 假-CPAP）。该项目利用既定的黄金标准方法来评估睡眠（多导睡眠图） 以及交感神经活动和反应性（显微神经造影）。综上所述，本项目将确定 模拟“暴饮暴食”饮酒对神经心血管功能的影响 男性和女性酗酒者的心血管风险（即睡眠和清晨），并测试潜在的 缓解酒精引起的自主神经功能障碍的治疗策略（即 CPAP）。