Fish oil and neurovascular control in humans

描述(由申请人提供)：这项建议的广泛目标是研究鱼油(omega-3脂肪酸)对人类神经血管控制的影响。具体地说，该项目将研究鱼油对以下方面的影响：1)正常血压和高血压患者的静息血压和肌交感神经活性(MSNA)，以及2)正常血压和高血压患者的神经血管对精神压力的反应。本项目的具体目标是：1.确定鱼油对人体血压和静息MSNA的影响。在为期八周的鱼油补充期前后，将测量静息血压和MSNA。血压正常和高血压的受试者都将被研究。据推测，鱼油将降低高血压患者的血压，血压的降低将与静息MSNA的减少相关。2.探讨鱼油对精神应激小鼠血压及MSNA反应的影响。在八周的鱼油补充期之前和之后，将直接从腓神经测量MSNA对精神压力的反应。血压正常和高血压的受试者都将被研究。据推测，鱼油会抑制高血压患者的血压和MSNA对精神压力的反应。3.探讨鱼油对心理应激小鼠前臂和小腿血管反应的影响。在8周的鱼油补充期之前和之后，将使用静脉闭塞体积描记术同时记录前臂和小腿对精神应激的血流反应。血压正常和高血压的受试者都将被研究。据推测，鱼油会增强对精神压力的前臂血管扩张反应，这种反应在高血压受试者中会更明显。4.探讨鱼油对精神应激大鼠交感神经和血管恢复反应的影响。精神压力后的血压、MSNA和血流量将在为期八周的鱼油补充期前后进行测量。血压正常和高血压的受试者都将被研究。据推测，在精神压力后，鱼油将减少血压、MSNA和血流恢复到基线状态所需的时间。鱼油可以降低心血管疾病的发病率，但这种关系背后的机制尚不清楚。该项目将提供关于鱼油对正常血压和高血压人类神经血管控制的影响的新知识。

DESCRIPTION (provided by applicant): The broad objective of this proposal is to examine the influence of fish oil (omega-3 fatty acids) on neurovascular control in humans. Specifically, this project will examine the effect of fish oil on: 1) resting blood pressure and muscle sympathetic nerve activity (MSNA) in normotensive and hypertensive individuals, and 2) neurovascular responses to mental stress in normotensive and hypertensive individuals. The specific aims of this project are: 1. To determine the effect of fish oil on blood pressure and MSNA at rest in humans. Resting blood pressure and MSNA will be measured before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will reduce blood pressure in hypertensive subjects, and that reductions in blood pressure will be associated with reductions in resting MSNA. 2. To determine the effect of fish oil on blood pressure and MSNA responses to mental stress. MSNA responses to mental stress will be measured directly from the peroneal nerve before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will inhibit blood pressure and MSNA responses to mental stress in hypertensive subjects. 3. To determine the effect of fish oil on forearm and calf vascular responses to mental stress. Forearm and calf blood flow responses to mental stress will be simultaneously recorded using venous occlusion plethysmography before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will enhance the forearm vasodilation response to mental stress, and that this response will be more dramatic in hypertensive subjects. 4. To determine the effect of fish oil on sympathetic and vascular recovery responses to mental stress. Post mental-stress blood pressure, MSNA and blood flow will be measured before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will reduce the amount of time required to return blood pressure, MSNA, and blood flow to baseline conditions after mental stress. Fish oil reduces the incidence of cardiovascular disease, but the mechanisms underlying this relationship remain unclear. This project will provide new knowledge regarding the effect of fish oil on neurovascular control in both normotensive and hypertensive humans.