Alcohol and Neurovascular Control in Humans

酒精与人类神经血管控制

• 批准号: 10677281
• 负责人: Jason R Carter
• 金额: $ 20万
• 依托单位: BAYLOR UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-05 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10677281
• 关键词: Alcohol; Neurovascular; Control; Humans

Project Summary There is wide-spread recognition that ‘binge’ alcohol consumption is associated with increased cardiovascular risk, but much of this is based on epidemiological studies and mechanisms remain poorly understood. Sympathetic overactivity has been suggested as a potential mechanism for alcohol-mediated cardiovascular disease, but direct evidence is lacking. The proposed project represents our first step in the pursuit of a long- term goal to explore alcohol-mediated hypertension, stroke, and sudden cardiac death, and practical interventions that might reduce the incidence of these cardiovascular conditions. The proposed project focuses on the impact of evening alcohol consumption on nocturnal and early morning autonomic function and reactivity in male and female binge drinkers. In aim 1, will determine the effect of evening alcohol consumption on nocturnal autonomic control and sympathetic neural responsiveness the subsequent morning. Aim 2 will determine the influence of sex (male vs. female) and the ovarian cycle (early follicular vs. midluteal phase) on sympathetic neural responsiveness to evening alcohol in humans. Aim 3 will determine if continuous positive airway pressure (CPAP) blunts alcohol-mediated sympathoexcitation at night and early morning. An exploratory aim will determine if autonomic responses to alcohol and CPAP are associated with affective states and psychomotor performance. Our central hypothesis is that evening alcohol consumption will elicit sympathetic overactivity at night and the subsequent morning, and that this sympathoexcitation will be augmented women and blunted after CPAP treatment. The novelty and innovation of this project is that our mechanistic aims are bolstered with an interventional aim that includes a randomized, control trial (CPAP vs. sham-CPAP). The project utilizes established, gold-standard methods for assessing sleep (polysomnography) and sympathetic neural activity and reactivity (microneurography). In summary, this project will determine the impact of simulated ‘binge’ alcohol consumption on neural cardiovascular function at times of elevated cardiovascular risk (i.e., sleep and early morning) in male and female binge drinkers, and test a potential therapeutic strategy (i.e., CPAP) to blunt alcohol-induced autonomic dysfunction.

项目总结

项目成果

Muscle Sympathetic Nerve Reactivity to Trier Social Stress Test.

肌肉交感神经对特里尔社会压力测试的反应。

• 发表时间: 2022
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Bigalke,JeremyA;Greenlund,IanM;Nicevski,JenniferR;Tikkanen,AnneL;Carter,JasonR
• 通讯作者: Carter,JasonR

Evening binge alcohol disrupts cardiovagal tone and baroreflex function during polysomnographic sleep.

晚上暴饮暴食会扰乱多导睡眠期间的心迷走神经张力和压力感受反射功能。

• DOI: 10.1093/sleep/zsab130
• 发表时间: 2021
• 期刊: Sleep
• 影响因子: 5.6
• 作者: Greenlund,IanM;Bigalke,JeremyA;Tikkanen,AnneL;Durocher,JohnJ;Smoot,CarlA;Carter,JasonR
• 通讯作者: Carter,JasonR

Sex still matters in cardiovascular research.

性别在心血管研究中仍然很重要。

• DOI: 10.1152/ajpheart.00643.2022
• 发表时间: 2023
• 期刊: American journal of physiology. Heart and circulatory physiology
• 作者: Lindsey,MerryL;Carter,JasonR;Ripplinger,CrystalM;Kassiri,Zamaneh;HansellKeehan,Kara;Brunt,KeithR;Kirk,JonathanA;Kleinbongard,Petra;LeBlanc,AmandaJ
• 通讯作者: LeBlanc,AmandaJ

Spring cleaning: freshening up the portfolio.

春季大扫除：更新投资组合。

• DOI: 10.1152/ajpheart.00219.2023
• 发表时间: 2023
• 期刊: American journal of physiology. Heart and circulatory physiology
• 作者: Lindsey,MerryL;Kassiri,Zamaneh;LeBlanc,AmandaJ;Ripplinger,CrystalM;Kirk,JonathanA;Carter,JasonR;Kleinbongard,Petra;Brunt,KeithR
• 通讯作者: Brunt,KeithR

Sex differences in self-report anxiety and sleep quality during COVID-19 stay-at-home orders.

• DOI: 10.1186/s13293-020-00333-4
• 发表时间: 2020-10-13
• 期刊: Biology of sex differences
• 影响因子: 7.9
• 作者: Bigalke JA;Greenlund IM;Carter JR
• 通讯作者: Carter JR