Sleep deprivation and neural cardiovascular control in postmenopausal women

描述（由申请人提供）：流行病学研究报告了睡眠时间短与高血压之间的联系，有证据表明，与男性相比，女性的这种关系可能更强。我们实验室最近的工作表明，完全睡眠剥夺（TSD）会导致年轻男性和女性的交感神经反应不同。尽管与衰老相关的心血管疾病风险增加，但睡眠剥夺，交感神经活动和动脉血压之间的关系仍然局限于年轻，健康的个体。拟议的项目将全面检查交感神经和心血管反应TSD在老年人，包括绝经后妇女。该项目包括三个具体目标。目的1将确定TSD是否改变绝经后妇女的动脉血压和交感神经活动。目的2将确定TSD是否改变绝经后妇女对急性实验室应激源的神经心血管反应。目标3是具体的学术研究增强奖（R15）使命，并将提供本科生和研究生从我们的机构有机会充分参与有关睡眠和心血管生理学的生物医学研究。我们的中心假设是，TSD将引起急性高血压和交感神经过度活跃的老年人，这种神经心血管功能障碍将是最戏剧性的绝经后妇女。我们将采用一种新的实验方法（随机，交叉设计; TSD与正常睡眠），包括通过显微神经造影术和其他关键心血管变量的综合分析交感神经活动的金标准分析。这项拟议的研究将补充最近的流行病学和观察性研究，提供有关睡眠剥夺对老年人交感神经控制影响的重要机制见解。此外，该项目还涉及最新的NIH睡眠障碍研究计划中概述的三个优先领域。

DESCRIPTION (provided by applicant): Epidemiological studies report a link between short sleep duration and hypertension, and there is evidence to suggest this relationship might be stronger in women when compared to men. Recent work from our laboratory demonstrates that total sleep deprivation (TSD) elicits divergent sympathetic neural responses in young men and women. Despite the heightened risk of cardiovascular disease associated with aging, the relations between sleep deprivation, sympathetic neural activity, and arterial blood pressure remain confined to young, healthy individuals. The proposed project will comprehensively examine sympathetic neural and cardiovascular responses to TSD in older humans, including postmenopausal women. The project includes three specific aims. Aim 1 will determine if TSD alters arterial blood pressure and sympathetic neural activity in postmenopausal women. Aim 2 will determine if TSD alters neural cardiovascular reactivity to acute laboratory stressors in postmenopausal women. Aim 3 is specific to the Academic Research Enhancement Award (R15) mission, and will provide undergraduate and graduate students from our institution an opportunity to fully engage in biomedical research related to sleep and cardiovascular physiology. Our central hypothesis is that TSD will elicit acute hypertension and sympathetic overactivity in older humans, and that this neural cardiovascular dysfunction will be most dramatic in postmenopausal women. We will employ a novel experimental approach (randomized, crossover design; TSD vs. normal sleep) that includes the gold-standard analysis of sympathetic neural activity via microneurography and integrative analysis with other key cardiovascular variables. The proposed research will compliment recent epidemiological and observational studies by providing important mechanistic insight regarding the influence of sleep deprivation on sympathetic neural control in older adults. Moreover, this project addresses three priority areas outlined in the most recent NIH Sleep Disorders Research Plan.