Sleep deprivation and neural cardiovascular control in postmenopausal women

绝经后妇女的睡眠剥夺和神经心血管控制

• 批准号: 8687801
• 负责人: Jason R Carter
• 金额: $ 46.5万
• 依托单位: MICHIGAN TECHNOLOGICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8687801
• 关键词: Academic Research Enhancement Awards; Acute; Address; Adult; Aging; Area; Autonomic nervous system; Baroreflex; Biomedical Research; Blood Pressure; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Clinical; Complex; Coupled; Crossover Design; Data; Development; Elderly; Environment; Epidemiologic Studies; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Functional disorder; Goals; Gold; Grant; Human; Hypertension; Incidence; Individual; Institution; Laboratories; Learning; Life; Link; Longevity; Measures; Medicine; Menopause; Mentorship; Methodology; Mission; Modeling; Morbidity - disease rate; Observational Study; Outcome; Pattern; Physicians; Physiology; Play; Postmenopause; Prevalence; Psyche structure; Randomized; Reporting; Research; Research Infrastructure; Research Personnel; Research Training; Risk; Scientist; Sex Characteristics; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Stress; Students; Techniques; Testing; Therapeutic; United States National Institutes of Health; Universities; Woman; Work; cardiovascular disorder risk; cardiovascular risk factor; career; experience; graduate student; insight; men; mortality; neuroregulation; novel; older men; older women; pressure; programs; public health relevance; relating to nervous system; response; stressor; undergraduate student; young adult; young man; young woman

DESCRIPTION (provided by applicant): Epidemiological studies report a link between short sleep duration and hypertension, and there is evidence to suggest this relationship might be stronger in women when compared to men. Recent work from our laboratory demonstrates that total sleep deprivation (TSD) elicits divergent sympathetic neural responses in young men and women. Despite the heightened risk of cardiovascular disease associated with aging, the relations between sleep deprivation, sympathetic neural activity, and arterial blood pressure remain confined to young, healthy individuals. The proposed project will comprehensively examine sympathetic neural and cardiovascular responses to TSD in older humans, including postmenopausal women. The project includes three specific aims. Aim 1 will determine if TSD alters arterial blood pressure and sympathetic neural activity in postmenopausal women. Aim 2 will determine if TSD alters neural cardiovascular reactivity to acute laboratory stressors in postmenopausal women. Aim 3 is specific to the Academic Research Enhancement Award (R15) mission, and will provide undergraduate and graduate students from our institution an opportunity to fully engage in biomedical research related to sleep and cardiovascular physiology. Our central hypothesis is that TSD will elicit acute hypertension and sympathetic overactivity in older humans, and that this neural cardiovascular dysfunction will be most dramatic in postmenopausal women. We will employ a novel experimental approach (randomized, crossover design; TSD vs. normal sleep) that includes the gold-standard analysis of sympathetic neural activity via microneurography and integrative analysis with other key cardiovascular variables. The proposed research will compliment recent epidemiological and observational studies by providing important mechanistic insight regarding the influence of sleep deprivation on sympathetic neural control in older adults. Moreover, this project addresses three priority areas outlined in the most recent NIH Sleep Disorders Research Plan.

描述（由申请人提供）：流行病学研究报告睡眠时间短与高血压之间存在联系，并且有证据表明，与男性相比，女性的这种关系可能更强。我们实验室最近的研究表明，完全睡眠剥夺（TSD）会在年轻男性和女性中引发不同的交感神经反应。尽管与衰老相关的心血管疾病风险增加，但睡眠不足、交感神经活动和动脉血压之间的关系仍然仅限于年轻、健康的个体。拟议的项目将全面检查老年人（包括绝经后妇女）对 TSD 的交感神经和心血管反应。该项目包括三个具体目标。目标 1 将确定 TSD 是否会改变绝经后女性的动脉血压和交感神经活动。目标 2 将确定 TSD 是否会改变绝经后妇女对急性实验室应激源的神经心血管反应。目标 3 针对学术研究增强奖 (R15) 使命，将为我们机构的本科生和研究生提供充分参与与睡眠和心血管生理学相关的生物医学研究的机会。我们的中心假设是，TSD 会在老年人中引起急性高血压和交感神经过度活跃，而这种神经心血管功能障碍在绝经后女性中最为严重。我们将采用一种新颖的实验方法（随机、交叉设计；TSD 与正常睡眠），其中包括通过显微神经造影对交感神经活动进行金标准分析以及与其他关键心血管变量的综合分析。拟议的研究将通过提供有关睡眠剥夺对老年人交感神经控制影响的重要机制见解，对最近的流行病学和观察性研究进行补充。此外，该项目还涉及最新的 NIH 睡眠障碍研究计划中概述的三个优先领域。

项目成果

Growing Evidence Linking OSA During Rapid Eye Movement Sleep to Systemic Hypertension.

越来越多的证据表明快速眼动睡眠期间的 OSA 与全身性高血压有关。

• DOI: 10.1016/j.chest.2016.03.047
• 发表时间: 2016
• 期刊: Chest
• 影响因子: 9.6
• 作者: Mokhlesi,Babak;Carter,JasonR
• 通讯作者: Carter,JasonR

Sex Differences in the Risk of Incident Hypertension With Sleep Apnea: Does Postmenopausal Status Matter?

患有睡眠呼吸暂停的高血压风险的性别差异：绝经后状态重要吗？

• DOI: 10.1016/j.chest.2017.05.027
• 发表时间: 2017
• 期刊: Chest
• 影响因子: 9.6
• 作者: Carter,JasonR;Mokhlesi,Babak
• 通讯作者: Mokhlesi,Babak

Positive airway pressure improves nocturnal beat-to-beat blood pressure surges in obesity hypoventilation syndrome with obstructive sleep apnea.

气道正压通气可改善伴有阻塞性睡眠呼吸暂停的肥胖低通气综合征的夜间逐搏血压激增。

• DOI: 10.1152/ajpregu.00516.2015
• 发表时间: 2016
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Carter,JasonR;Fonkoue,IdaT;Grimaldi,Daniela;Emami,Leila;Gozal,David;Sullivan,ColinE;Mokhlesi,Babak
• 通讯作者: Mokhlesi,Babak