Superconducting Gradient Coil for Targeted Therapy by Micro-particle Navigation

描述（由申请人提供）：我们的提案介绍了有助于设计和制造三轴磁梯度线圈的新技术，用于人体动脉中携带药物的颗粒的体内导航，可通过MRI扫描仪跟踪。开发一种实用的体内粒子导航器可以带来非常有效的微创医学治疗，也许最重要的是将药物输送到癌组织。蒙特利尔理工大学纳米机器人实验室（NLEPM）通过使用MRI硬件演示了基于图像的粒子导航原理。NLEPM是我们的合作者，最近的工作表明，需要数百mT/m的磁场梯度来引导可以作为药物载体的微粒。我们提出的第一阶段工作旨在证明设计和制造超导梯度线圈的可行性，该线圈可以达到500 mT/m，并且可以安装在临床人体MRI扫描仪中。公共卫生相关性：我们的提案介绍了新技术，有助于设计和制造三轴磁梯度线圈，用于通过MRI扫描仪跟踪人体动脉中携带药物颗粒的体内导航。开发一种实用的体内粒子导航器可以带来非常有效的微创医学治疗，也许最重要的是将药物输送到癌组织。

DESCRIPTION (provided by applicant): Our proposal introduces novel technologies that facilitate designing and manufacturing three-axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue. The NanoRobotics Laboratory Ecole Polytechnique Montreal (NLEPM) has demonstrated principles of image-based particle navigation by use of MRI hardware. Recent work by NLEPM, who is a collaborator in our proposed work, has indicated a need for magnetic field gradients strength of hundreds of mT/m to navigate micro-particle that can be used as carries of drugs. Our proposed Phase I work intends to demonstrate the feasibility of design and manufacturing of superconducting gradient coils that can achieve 500 mT/m, and which can be installed inside clinical human MRI scanners. PUBLIC HEALTH RELEVANCE: Our proposal introduces novel technologies that facilitate designing and manufacturing three-axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue.