Portable Fiber Lasers for Multiphoton Endoscope

描述(申请人提供)：将开发一种基于全光纤的多光子内窥镜，用于从组织中获取体内MPM信号。一个飞秒光纤激光器和一个小光纤探头将使探测来自小范围的内腔和器官的MPM信号成为可能。PolarOnyx建议开发一种创新的高功率飞秒光纤激光器，通过光纤将不失真的飞秒光脉冲传输到组织，并使用光纤束收集从组织激发的MPM信号。使用全光纤组件，该系统将紧凑、便携和低成本。在第一阶段，将开发和优化用于MPM应用的飞秒光纤激光器。将设计一个微型探头来传递激发光和收集信号。将对激光束进行深度扫描，并使用光谱仪获取多光子光谱。在第二阶段，激光器将得到充分的优化，并与光纤探头集成在一起，走向真正的临床试验。

DESCRIPTION (provided by applicant): An all-fiber-based multiphoton endoscope will be developed for acquiring in vivo MPM signals from tissues. A femtosecond fiber laser and a small fiber probe will make it possible to detect MPM signals from small areas of internal cavities and organs. PolarOnyx proposes to develop an innovative high power femtosecond fiber laser with fiber delivering of undistorted femtosecond light pulses to tissues and a fiber bundle for collecting MPM signals excited from tissues. Using all-fiber-based components, the system will be compact, portable, and low-cost. In phase I, a femtosecond fiber laser will be developed and optimized for MPM applications. A miniature probe head will be designed to deliver excitation light and collect signals. Laser beam will be scanned in depth and multiphoton spectra will be acquired using a spectrograph. In phase II, the laser will be fully optimized and integrate with the fiber probe towards real clinic try.