COMPARING WHITE MATTER FIBER TRACTS IN HUMANS, APES & MONKEYS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目通过与我们最近的近亲黑猩猩进行比较，确定了人类大脑中与语言有关的白色纤维束的专门化。扩散张量成像被用来跟踪弓状束及其组成部分在死后和活的恒河猴，黑猩猩和人类的大脑。比较了不同半球和物种的解剖细节和通路强度。从确定性和概率纤维束成像算法的结果进行了比较。对工具使用途径的分析已经启动，目前正在进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project identifies specializations of the human brain within white matter fiber tracts known to be involved in language, by way of comparison with our closest living relative, the chimpanzee. Diffusion tensor imaging is used to track the arcuate fasciculus and its constituent segments in both post-mortem and living brains from rhesus macaques, chimpanzees and humans. Anatomical details and pathway strength were compared across hemispheres and species. Results from deterministic and probabilistic tractography algorithms were compared. Analysis of pathways involved in tool use has been initiated and is ongoing.