Identification of E-protein complexes controlling natural killer cell fate and tumour immunity

不同的免疫细胞类型对于有效的广谱免疫是必不可少的。主调节器控制这种多样性，并在抗原特异性免疫的发展中具有充分表征的作用。相比之下，我们缺乏对主调节因子如何控制抗原非特异性先天免疫的机械理解。了解这背后的机制将解释如何不同的白色血细胞可以发展，并揭示战略，以扭曲他们的发展，以提高人类的免疫力。

Diverse immune cell types are essential for effective broad-spectrum immunity. Master regulators control this diversity and have a well-characterized role in the development of antigen-specific immunity. In contrast, we lack mechanistic understanding of how master regulators control antigen-unspecific, innate immunity. Understanding the mechanism behind this will explain how diverse white blood cells can develop and reveal strategies to skew their development to improve immunity in humans.