EPISODIC MEMORY IN RHESUS MONKEYS SPATIAL & TEMPORAL CONTEXTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人类的有意识记忆分为两种类型。语义记忆由关于世界的事实组成：沙漠缺水；海鲜必须新鲜才能安全。情节记忆是回忆自传体事件的次要能力：有一次在沙漠徒步旅行中水用完了，有一次你在海滩派对上被宠坏的蛤肉弄病了。虽然许多实验表明猴子和其他动物都会记忆，但事实证明，很难在非人类的语义记忆和情节记忆之间做出这种重要的区分。开发区分猴子这两种记忆类型的程序，将使我们能够更有效地利用非人类模型系统来理解正常的人类认知和影响它的疾病。 我们已经开始在实验室里对猴子进行一次大型露天“觅食”记忆测试。我们已经成功地在这种开阔的领域背景下训练猴子进行物体识别，并开始训练样本匹配的工作。猴子完成这项任务的速度一直很慢，部分原因是空间偏见。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Conscious memory in humans is divided into two types. Semantic memory consists of facts about the world: water is scarce in the desert; seafood must be fresh to be safe. Episodic memory sub-serves the ability to recall autobiographical events: once running out of water on a desert hiking trip, the time you were sickened by spoiled clams at a beach party. While many experiments show that monkeys and other animals remember, it has proven difficult to make this important distinction between semantic and episodic memory in nonhumans. Developing procedures for distinguishing between these two types of memory in monkeys will permit us to make more effective use of nonhuman model systems for understanding normal human cognition and the diseases that affect it. We have begun training monkeys in a large open-field "foraging" memory test in the lab. We have successfully trained monkeys in object discriminations in this open-field context and have begun work on training matching to sample. Monkeys have been slow to acquire this task, in part because of spatial biases.