MONKEY BEHAVIORAL EFFECTS IN A SEMI-NATURALISTIC ENVIRONMENT

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 早期内侧颞叶功能障碍与许多发育性精神障碍（精神分裂症、自闭症、威廉姆斯综合征）相关，这些发育性精神障碍对年轻个体的正常认知发育具有显著影响，其跨越整个生命。 由于对这一大脑区域内特定结构的早期损伤的长期行为和认知后果知之甚少，特别是当动物在自然环境中饲养时，我们准备了双侧杏仁核神经毒性损伤的3周龄雄性猴子（N = 3）和假手术对照（N = 2），并将它们与它们的母亲一起替换在一个大的半-耶基斯野外考察站的自然主义社会团体 我们已经非常详细地跟踪了在生命的第一年中出现的与从属关系、社会地位和恐惧有关的物种特异性行为，以及性二态行为的出现。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Early medial temporal dysfunction is associated with many developmental mental disorders (schizophrenia, autism, Williams's syndrome) that have significant impact on the normal cognitive development of a young individual that spans the entire life. Because little is known on the long-term behavioral and cognitive consequences of early damage to specific structures within this brain region, specifically when the animals are raised in a naturalistic environment, we prepared 3-week-old male monkeys with bilateral neurotoxic amygdala lesions (N = 3) and sham-operated controls (N = 2) and have replaced them together with their mothers in a large semi-naturalistic social group at the Yerkes field station. We have followed in great detail the emergence of species-specific behaviors during the first year of life relating to affiliation, social status and fearfulness, and the appearance of sexually dimorphic behaviors.