EFFECTS OF CLOMIPHENE CITRATE ON THE UTERINE ENDOMETRIUM IN MACAQUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 克罗米芬(CC)是治疗女性不孕症最常用的抗雌激素药物。虽然CC在诱导排卵方面是成功的，但所获得的受孕数量远远低于预期。推测CC对子宫内膜有负面影响，从而影响着床。一项临床前研究正在进行中，以测试CC是否对灵长类子宫内膜具有抗雌激素作用。本研究将前瞻性地确定CC是否改变了雌性恒河猴月经周期卵泡期和黄体期子宫内膜的形态、组织学和生化特征。如果在非人类灵长类动物子宫内膜中观察到这种变化，将对具有更具组织特异性作用机制的新化合物进行评估。开发有效的促排卵新药，但不会对子宫产生不良影响，将有助于改善妇女的不孕症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Clomiphene citrate (CC) is the most commonly used anti-estrogen for treating infertility in women. Although CC is successful at inducing ovulation, the number of pregnancies achieved is much lower than expected. It is hypothesized that CC exerts negative effects on the uterine endometrium that impair implantation. A pre-clinical study is underway to test whether CC has anti-estrogenic effects on the primate endometrium. This study will prospectively determine whether CC alters the morphological, histological and biochemical characteristics of the endometrium during the follicular and luteal phases of the menstrual cycle in female rhesus monkeys. If such alterations are observed in the nonhuman primate endometrium, new compounds with a more tissue-specific mechanism of action will be evaluated. Development of novel agents that are effective for ovulation induction, but without adverse effects on the uterus, will aid in ameliorating infertility in women.