LSU DENTAL COBRE: STATISTICAL CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 导言：统计核心的总体任务是为科布雷的项目在研究设计、样本量估计/统计能力分析、统计方法和数据库管理等领域提供支助。统计核心不仅在提供统计服务方面发挥关键作用，而且在促进初级首席调查员了解研究设计和数据分析的重要性方面也发挥了重要作用。 目标：统计核心的活动以下列5个具体目标为指导。(1)就研究设计、样本量估计、统计分析计划和研究建议咨询初级原则调查人员(JPI)。(2)数据库管理系统和质量控制程序的开发和管理。(3)研究数据的统计分析、结果的表述和解释。(4)教育服务，支持研究人员在研究设计和分析方面的发展。(5)加强统计核心服务，为COBRE带来最先进的能力。 方法：统计核心成员(Mercante博士、Peter博士、Simonsen博士和Hagan先生)定期参加由JPIS提出或应JPIS要求举办的研讨会、粉笔演讲、资助者、特邀演讲。此外，梅坎特博士还定期参加初级辅导员会议。统计核心成员可由每个联合方案执行机构审查，并就赠款提交、摘要和论文的编写和提交提供咨询。统计核心的所有成员都积极参与编写和讲授由10部分组成的讲义系列，专门为满足当前日本宣传局小组的需要和兴趣而设计。 结果：统计核心成功地招募了一位医学硕士生物统计学家Joseph Hagan先生加入统计核心，接替Joanna Du女士的职责，Joanna Du女士在2007年底她的丈夫搬到华盛顿特区时辞职。Mercante博士、Peter博士和Simonsen博士以及Joe Hagan先生都向JPIS介绍了作为教学系列的一部分的研讨会。主题包括基本流行病学研究设计和措施，统计和临床试验中的设计和分析问题，以及数据库管理。Mercante博士曾与徐博士合作提交和重新提交资助，就实验设计、样本量估计和统计分析提供建议。 讨论：统计核心在实现所述目标方面取得了重大进展，并将继续与各JPIS密切合作，为其研究提供指导和支持。特别是，《统计核心》极大地扩展和加强了其教学系列和网站，以便向初级绩效指标提供统计资源。Mercante博士曾多次与徐博士会面，讨论增强对他的R01应用程序的统计支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: The overall mission of the Statistical Core is to provide support in the areas of study design, sample size estimation/statistical power analyses, statistical methodology and database management for the projects in the COBRE. The Statistical Core has a crucial role in not only providing statistical services but in contributing to the mentoring process for the junior principal investigators (JPIs) in developing their understanding of the importance of study design and data analysis. Objective: The activities of the Statistical Core are guided by the following 5 specific aims. (1) Consultation with Junior Principle Investigators (JPIs) on study design, sample size estimation, statistical analysis plan, and research proposal. (2) Development and management of database management system and quality control procedures. (3) Statistical analysis of study data, presentation and interpretation of results. (4) Educational services to support investigator development in study design and analysis. (5) Enhancement of statistical core services to bring state of the art capabilities to the COBRE. Methods: The Statistical Core members (Drs. Mercante, Peters, and Simonsen, and Mr. Hagan) regularly attend seminars, chalk talks, grantseekers, invited talks presented by or at the request of the JPIs. In addition, Dr. Mercante regularly attends secondary mentor meetings for the JPIs. Members of the Statistical Core are available to each JPI to review and advise JPIs on grant submissions, abstract and paper preparations and submission. All members of the Statistical Core actively participate in developing and presenting lectures in a 10-part didactic series specifically structured to meet the needs and interests of the current JPI team. Results: The Statistical Core successfully recruited a M.S. biostatistician, Mr. Joseph Hagan, into the Statistical Core to take over the responsibilities Ms. Joanna Du, who resigned in late 2007 when her husband was relocated to Washington, D.C. Drs. Mercante, Peters, and Simonsen and Mr Joe Hagan all presented seminars as part of the didactic series to the JPIs. Topics included basic epidemiological study design and measures, design and analysis issues in statistics and clinical trials, and database management. Dr. Mercante has collaborated with Dr. Xu on his grant submission and re-submission, providing advice on experimental design, sample size estimation and statistical analysis. Discussion: The Statistical Core has made significant progress towards the stated objectives and will continue to work closely with the JPIs to provide guidance and support for their research. In particular, the Statistical Core has greatly expanded and enhanced its didactic series and website for providing statistical resources to the JPIs. Dr. Mercante has met with Dr. Xu on multiple occasions to discuss enhanced statistical support of his R01 application.