LIPID METABOLITES AND PATHWAYS STRATEGY CONSORTIUM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目得到了NIGMS胶水赠款的支持。整个计划有以下目标：(1)分离和检测特定细胞中的所有脂类，并发现和表征可能存在的任何新的脂类。(2)对存在的每种脂代谢产物进行定量，并对其在细胞功能过程中的水平和位置的变化进行定量。(3)定义每种脂类的生化途径，并开发定义相互作用网络的脂类图谱。为了帮助中性脂质核心，脂质组学重点领域，由R.C.墨菲，大学。在科罗拉多州健康科学中心，BUSM MS资源协助确定新型中性脂质的结构。C.E.Costello为LipidMaps计划提供脂类的质谱分析新方法方面的专业知识，并参加LipidMaps调查人员的年度会议。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is supported by an NIGMS Glue Grant. The overall program has the following objectives: (1) Separate and detect all of the lipids in a specific cell and discover and characterize any novel lipids that may be present. (2) Quantitate each of the lipid metabolites present and quantitate the changes in their levels and location during cellular function. (3) Define the biochemical pathways for each lipid and develop lipid maps which define the interaction networks. To aid the Neutral Lipids Core, Lipidomics Focus Area, directed by R.C. Murphy, Univ. Colorado Health Sciences Center, the BUSM MS Resource assists in the structural determinations of novel neutral lipids. C. E. Costello provides expertise on new methods for mass spectral analysis of lipids to the Lipid MAPS program and attends the annual meeting of LipidMaps investigators.