ELECTROSTATIC SWITCH FOR PKA ACTIVATION BY CAMP

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 环腺苷酸（cAMP）是一种非常重要和通用的小分子第二信使，参与调节无数细胞事件。保守的cAMP结合结构域存在于大量蛋白质中，包括蛋白激酶A（PKA）、EPAC、环核苷酸门控通道和介导cAMP对蛋白质功能的变构效应的cAMP调节的细菌转录因子。随着cAMP类似物越来越多地被用作治疗剂，特别是用于癌症，对激活的分子特征的理解可能有助于选择性靶向某些效应途径的特异性抑制剂和激动剂的合理开发。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cyclic AMP (cAMP) is an extremely important and universal small molecule second messenger involved in the regulation of a myriad of cellular events. A conserved cAMP binding domain is present in a large number of proteins, including protein kinase A (PKA), EPAC, the cyclic-nucleotide gated channels, and cAMP-regulated bacterial transcription factors that mediate the allosteric effects of cAMP on protein functions. As cAMP analogs are increasingly being used as therapeutics, especially for cancer, an understanding of the molecular features of activation may aid in the rational development of specific inhibitors and agonists that selectively target certain effector pathways.