GLYCAN STRUCTURE & POSITION OF GLYCOSYLATION SITES ON DSIAT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是确定果蝇唾液酸转移酶糖基化位点的结构和位置 蛋白质，DSiaT. DSiaT代表动物的原口类谱系中第一个表征的唾液酸转移酶（Koles et al. 2004，JBC 279：4346-435）。这种唾液酸转移酶与脊椎动物唾液酸转移酶的ST 6 GAL家族密切相关， 这表明DSiaT可能代表了进化最古老的matazoan唾液酸转移酶类型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study was to determine the structure and position of glycosylation sites on the Drosophila sialyltransferase protein, DSiaT. DSiaT represents the first characterized sialyltransferase in the protostome lineage of animals (Koles et al. 2004, JBC 279: 4346-435). This sialyltransferase is closely related to the ST6GAL family of vertebrate sialyltransferases, which indicates that DSiaT may represent the most evolutionary ancient type of matazoan sialyltransferases.