CORE--DATA MANAGMENENT AND STATISTICS CORE

数据管理和统计核心(以下简称数据核心)在两个领域支持MADRC：(1)数据管理；(2)实验设计和统计分析。 数据管理的具体目标是继续从核心、少数群体卫星和研究研究收集MADRC数据，并将这些信息纳入现有的关系型多用户研究数据库。这个数据库包括患者和正常对照对象的登记表，这些患者和正常对照对象签署了同意发布他们的医疗记录以可能参与研究研究的表格，并已由临床核心进行评估，包括关于他们是否适合进行临床研究的信息；以及关于正在参与研究研究或正在进行纵向跟踪的患者和正常对照对象子集的研究数据。数据核心将与项目和其他核心合作，确保MADRC数据库中数据的准确性和完整性，使用已建立的数据输入、验证和验证程序，必要时进行修改，以符合HTPAA关于患者保密的新指南。核心将开发和扩大数据库的范围，以满足国家阿尔茨海默病协调中心(NACC)对数据收集和实时数据提交的新要求，在保持患者机密性和个人研究人员数据完整性的条件下，核心的目标是就与统计设计和分析相关的所有问题领导和协助与MADRC有关的项目；在向MADRC和资助机构提交与痴呆症相关主题的研究研究之前，为研究人员提供统计咨询；以及审查试点项目和其他要求使用MADRC资源的研究项目的统计方面。

The Data Management and Statistics Core (henceforth abbreviated to Data Core) supports the MADRC in two areas: (1) data management; and (2) experimental design and statistical analysis. Data management specific aims are to continue to collect MADRC data from cores, the Minority Satellite and research studies and integrate this information in an existing relational multi-user research database. This database consists of a registry of patients and normal control subjects who have signed a form consenting the release of their medical records for potential participation in research studies, and have been evaluated by the Clinical Core, including information on their appropriateness for clinical studies; and research data on the subset of patients and normal control subjects who are participating in research studies, or are being followed longitudinally. The Data Core will work with projects and other cores to assure the accuracy and completeness of the data in the MADRC database using established procedures for data entry, validation and verification, modified where necessary to conform with new HTPAA guidelines for patient confidentiality. The Core will develop and extend the scope of the database to accommodate new requirements for data collection and real-time data submission from the National Alzheimer's Coordinating Center (NACC), under conditions that maintain patient confidentiality and the integrity of individual investigators' data Experimental Design and Statistical Analysis Aims of the Core are to provide leadership and assistance for MADRC-affiliated projects on all issues relating to statistical design and analysis; to provide statistical consultation for investigators in the design and analysis of research studies on dementia-related topics prior to their submission to the MADRC and funding agencies; and to provide review of statistical aspects of pilot projects and other research projects requesting use of MADRC resources.