T1P-WEIGHTED MR IMAGING OF NORMAL ARTICULAR CARTILAGE AND EARLY OSTEOARTHRITIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 骨性关节炎影响65岁以上人口的一半以上，并具有显著的 对老年人的生活质量产生负面影响。美国的经济成本来自 据估计，农业增加值占国内生产总值的1%以上。 最近的研究导致了在实验动物中使用的药物的开发 已经被证明能够有效地保护软骨中的大分子免受破坏 阻止了骨质疏松症的进展。因为OA的自然历史悠久(10-20年)验证 这些药物在人类身上的疗效将需要一种技术来直接评估它们的 对大分子基质的影响。 研究目标： 1.获得T1p在整个关节软骨中的空间差异。 无症状受试者的膝盖。 2.对不同年龄组关节软骨T1p值的差异进行估计。 无症状受试者的年龄组。 3.证明T1p加权磁共振成像和计算的T1p图可以可靠地检测到 关节镜下确定的关节软骨微小骨性关节炎的病灶。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoarthritis affects more than half of the population above the age of 65 and has significant negative impact on the quality of life of elderly individuals. The economic costs in the US from OA have been estimated to be more than 1% of the gross domestic product. Recent research has led to the development of drugs that in experimental animals that have proven capable of protecting the macromolecules in cartilage from breakdown, effectively halting the progression of OA. Because of the long natural history of OA (10-20 years) validating the efficacy of these drugs in humans will require a technique that can directly assess their effect on the macromolecular matrix. Study Aims: 1. To obtain an estimate of the spatial difference of T1p throughout articular cartilage of the knee in asymptomatic subjects. 2. To obtain an estimate of the differences of T1p values in articular cartilage between different age groups of asymptomatic subjects. 3. To demonstrate that T1p-weighted MR imaging and calculated T1p maps can reliably detect foci of minimal osteoarthritis of articular cartilage as determined by arthoscopy.