CANCER CENTER SUPPORT GRANT

描述(由申请人提供)：本申请代表伯纳姆研究所癌症中心的癌症中心支持补助金(CCSG)的竞争性续签。自1981年以来，癌症中心一直接受来自国家癌症研究所的CCSG资助。伯纳姆研究所是一个独立的非营利性组织，致力于与癌症和其他退行性疾病相关的基础研究。自CCSG上次竞争性更新以来，该研究所的癌症中心成员已从34名研究人员增加到目前的54名主要、次要和附属成员。此外，该研究所现在有一个规模较小的神经科学和衰老研究中心。然而，到目前为止，与癌症相关的研究仍然是伯纳姆研究所的主要科学重点。癌症中心包括6个科学项目：(1)细胞黏附和细胞外基质；(2)糖生物学；(3)肿瘤发育生物学；(4)癌症遗传学和表观遗传学；(5)信号转导研究；(6)细胞凋亡和细胞死亡。在过去的资助期间，癌症中心进一步加强了其在细胞-基质相互作用、糖生物学和细胞死亡机制领域的科学地位。已经开发了几个新的共享资源(例如，高通量细胞分析设施)，并招募了11名新的全职教员作为主要或次要成员加入癌症中心项目。 发展中的研究领域包括有丝分裂和应激诱导的信号转导、基因组监测和遗传不稳定性。在下一个资金阶段，我们对中心发展的总体计划是将化学生物学整合到我们每个项目所特有的细胞生物学和结构生物学的现有混合中。我们的目标是鼓励使用小分子作为正常细胞和癌细胞生物学研究的探针，并开发可能作为进一步开发抗癌药物的候选先导化合物。为了实现这些目标，癌症中心将促进与化学文库筛选、高通量细胞分析、基因微阵列分析和蛋白质组学相关的研究活动。此外，我们计划通过招聘新的教员进入该中心，建立更多的化学和化学生物学专业知识。我们的总体目标是在我们基于发现的研究和癌症预防和治疗新策略的开发之间建立更直接的联系。

DESCRIPTION (provided by applicant): The present application represents the competitive renewal of the Cancer Center Support Grant (CCSG) for The Burnham Institute's Cancer Center. The Cancer Center has been a recipient of CCSG support from the National Cancer Institute since 1981. The Burnham Institute is an independent, non-profit organization dedicated to basic research related to cancer and other degenerative diseases. Since the last competitive renewal of the CCSG, the Institute's Cancer Center membership has increased from 34 investigators to its current total of 54 primary, secondary and adjunct members. In addition, the Institute now contains a smaller Neurosciences and Aging Research Center. However, cancer-related research remains by far the predominant scientific focus of The Burnham Institute. The Cancer Center contains 6 scientific programs: (1) Cell Adhesion and Extracellular Matrix; (2) Glycobiology; (3) Oncodevelopmental Biology; (4) Cancer Genetics and Epigenetics; (5) Signal Transduction Research; and (6) Apoptosis and Cell Death. During the past funding period, the Cancer Center has further enhanced its position of scientific prominence in the areas of cell-matrix interactions, glycobiology and cell death mechanisms. Several new shared resources have been developed (e.g., the High-throughput Cell Analysis Facility), and 11 new, full-time faculty members have been recruited into Cancer Center Programs as primary or secondary members. Developing areas of research strength include mitogenic and stress-induced signal transduction, genome surveillance, and genetic instability. During the next funding period, our overarching plan for Center development is to integrate chemical biology into the existing blend of cell biology and structural biology that characterizes each of our programs. Our goals are to encourage the use of small molecules as probes for studies of normal and cancer cell biology, and to develop lead compounds that might serve as candidates for further development as anticancer drugs. To accomplish these objectives, the Cancer Center will facilitate research activities related to chemical library screening, high-throughput cell analysis, gene microarray analysis, and proteomics. In addition, we plan to build additional expertise in chemistry and chemical biology through the recruitment of new faculty into the Center. Our overall objective is to forge more direct connections between our discovery-based research and the development of novel strategies for cancer prevention and therapy.