DEVELOPED A VIEWER FOR CHIP-SEQ DATA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 开发了用于显示染色体上的ChIP-Seq数据的查看器。查看器允许用户获得对基因组的观察的概述，以及感兴趣区域的详细视图，其中ChIP-Seq数据与染色体注释一起显示，并带有指向有关基因信息的超链接。查看器是基于网络的，以支持协作。数据被提交到一个队列中进行处理，所有页面都是预先生成的，以便在查看期间进行快速访问。观察器最初用于分析布氏锥虫中不同修饰状态的组蛋白结合的位置（乔治克罗斯实验室）。后来，观众也被用来调查复制停滞在酿酒酵母中的高表达基因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A viewer to display ChIP-Seq data on chromosomes was developed. The viewer allows the user to both get an overview of the observations over the genome, and a detailed view of regions of interest where the ChIP-Seq data is shown with chromosomal annotations with hyperlinks to information about the genes. The viewer is web-based to support collaborations. The data is submitted to a queue for processing and all pages are pregenerated to allow fast access during viewing. The viewer was initially used to analyze the locations for binding of histones in different modification states in Trypanosoma bruzei (George Cross Lab). Later, the viewer was also used to investigate replication arrest at highly expressed genes in Sacharomyces cerevisiae.