London Brain Bank for research on neurodegenerative diseases: a resource for the neuroscience research community

脑库项目的目的是通过向神经科学家提供脑组织，促进对神经退行性疾病和神经系统疾病的理解，并使研究成为可能。脑库收集来自各种疾病的大脑和脊髓组织，包括痴呆症（如阿尔茨海默病和路易体痴呆症），自闭症，精神分裂症和运动神经元疾病。此外，还从没有这种情况的捐赠者那里收集组织，作为科学研究中的健康比较。神经病理学家对脑组织进行详细研究，并根据国际商定的标准诊断疾病。各种固定状态下的脑组织样本，如冷冻和福尔马林固定，可供英国各地的神经科学研究中心使用，以帮助研究脑部疾病的原因并开发新的诊断和治疗策略。脑库通过道德上批准的知情同意方案实现组织捐赠，我们的目标是确保捐赠者的护理，并与捐赠者家庭保持联系，告知他们诊断和研究进展。我们遵循最新的脑银行最佳实践伦理指南，从招募捐赠者和同意死后检查到组织收集，样本储存和向研究人员提供组织的黄金标准。进一步的目标是为神经科学家提供专业的教学，培训，信息和教育资源。我们还通过科学会议、公众开放日、与慈善机构的合作以及MRC通讯来推广脑库知识。

The purpose of the Brain Bank project is to advance the understanding, and enable research into the underlying causes, of neurodegenerative and neurological diseases by providing brain tissue to neuroscientists. The Brain Bank collects brain and spinal cord tissue from a variety of diseases, including Dementia (such as Alzheimer’s disease and Lewy Body Dementia), Autism, Schizophrenia and Motor Neurone Disease. Tissue is also collected from donors without such conditions to act as a healthy comparison in scientific studies.Brain tissue is studied in detail by neuropathologists and the disease is diagnosed according to internationally agreed criteria. Samples of brain tissue in various fixation states, such as frozen and formalin-fixed, are made available to Neuroscience research centres throughout the UK to help study the causes and develop new diagnostic and therapeutic strategies for brain diseases. The Brain Bank enables donation of tissue through an ethically approved programme of informed consent, we aim to ensure donor care and keep contact with donor families, informing them of diagnosis and research progress. We follow the most recent ethical guidelines for best practice in Brain Banking, from recruiting donors and consent for post mortem examination to gold-standards of tissue collection, sample storage and the provision of tissue to researchers.A further objective is to provide professional teaching, training, information and educational resources for neuroscientists. We also promote knowledge of brain banking through scientific meetings, public open days, collaboration with charities and MRC newsletters.