Training Grant in Neurodevelopmental Disabilities

描述(由申请人提供)：项目摘要：我们的神经发育障碍跨学科机构培训计划，总部设在费城儿童医院(CHOP)和宾夕法尼亚大学(U Of P)，旨在培训医学博士和博士研究生，研究重点是导致智力障碍和发育障碍的遗传和获得性障碍。27名导师将参加这个项目的第二次竞争性更新；20名主要在CHOP，7名主要在P大学。所有人都深度参与生物医学研究生教育，并通过相互的研究项目和拨款密切联系在一起。除了指导研究培训，我们的课程强调：1)医学博士和博士的临床实践要求，2)通过P大学研究生课程的正式课程工作，3)负责任的研究行为培训，4)生物统计学培训和5)涵盖各种重要生存技能的研讨会，包括科学写作、公开演示、拨款撰写研讨会、实验室管理和职业发展技能。在我们项目的前9年里，我们接受了19名实习生；4名医学博士，14名博士，1名医学博士/博士。这些受训人员中有11名是女性，其中4名受训人员是代表性不足的少数民族。在完成培训的14人中，8人在教员职位，2人在其他学术机构继续培训，1人是制药公司的高级研究科学家，1人是科学管理人员，1人是私人执业。我们要求继续支持4名博士后研究员/年，并希望将我们的计划扩大到包括支持2名博士后研究员/年。我们的目标仍然是提供一个不同于CHOP或P大学任何其他培训项目的培训项目，专注于后天和遗传导致发育障碍的原因。该计划受益于所处的卓越环境，该环境将大量资源投入到培训、基础生物医学研究以及真正的“从长椅到床边”的翻译研究方法上。项目相关性：据估计，美国有10%的家庭患有发育障碍。迫切需要愿意并能够应用现代研究方法来阐明这些疾病的发病机制和病理生理的研究人员，以便找到新的、更有效的治疗干预措施。该计划致力于满足这一需求。

DESCRIPTION (provided by applicant): Project Summary: The aim of our interdisciplinary Institutional Training Program in Neurodevelopmental Disabilities, based at The Children's Hospital of Philadelphia (CHOP) and The University of Pennsylvania (U of P), is to train MD and PhD pre-/post-doctoral fellows in research focused on genetic and acquired disorders that cause mental retardation and developmental disability. Twenty-seven mentors will participate in this second competitive renewal of this program; 20 are based primarily at CHOP, and 7 primarily at the U of P. All are heavily involved in biomedical graduate education and are closely interlinked by mutual research projects and grants. In addition to mentored research training, our curriculum emphasizes: 1) a clinical practicum requirement for both MDs and PhDs, 2) formal course work through the U of P Graduate Studies Program, 3) training in responsible conduct of research, 4) training in biostatistics and 5) workshops that cover a variety of important survival skills, including scientific writing, public presentations, grant writing workshops, laboratory management, and career advancement skills. During the first 9 years of our program, we accepted 19 Trainees; 4 were MDs, 14 were PhDs, and 1 was a MD/PhD. 11 of these trainees were female and 4 of these trainees were under-represented minorities. Of the 14 who have completed training, 8 are in faculty positions, 2 are continuing their training at other academic institutions, 1 is a senior research scientist at a pharmaceutical company, 1 is a scientific administrator, and 1 is in private practice. We request continued support for 4 postdoctoral fellows/year and would like to expand our program to include support for 2 pre-doctoral fellows/year. Our goal remains focused on providing a training program unlike any other here at the CHOP or the U of P that is focused on acquired and genetic causes of developmental disability. This program benefits from being in an outstanding environment that commits substantial resources to training, to basic biomedical research, and to a true 'bench to bedside' approach to translational research. Project Relevance: It has been estimated that developmental disabilities affect 10% of all families in the USA. Researchers are urgently needed who are willing and able to apply modern research methods to elucidating the pathogenesis and pathophysiology of these disorders, so that new and more effective therapeutic interventions can be identified. This program strives to fill this need.