Pregnancy Exposure to Environmental Contaminants: Research and Prevention

越来越多的大量文献将在胎儿发育的特定时期暴露于化学品与以下因素联系起来：不良分娩结局，如早产和低出生体重；儿童疾病，如神经发育障碍和癌症；以及后来出现的成人疾病，如糖尿病和心血管疾病。此外，大型国家生物监测研究报告称，几乎无处不在 暴露在美国人口中的许多环境污染物，引发了人们到底是如何接触到这些污染物的问题，以及这会产生什么影响。此外，对妊娠中期的研究证实，胎盘并不是外来化学物质的屏障，而且还表明，胎儿-在一个 当它缺乏排毒机制的时候--可能会经历比母亲更高的暴露水平。我们建议组建一个新的、综合的、多学科的研究小组，他们来自生物、临床和 加州大学旧金山分校妊娠暴露和环境污染物形成中心的流行病学科学。 PEEC形成中心的主题是通过一种创新的多学科方法促进我们对环境化学品暴露如何影响早期发育的理解，1)将怀孕期间对环境化学品来源和暴露的研究与关于以下方面的基础生物学研究相结合 化学品暴露可能会扰乱早期发育，2)将这些科学发现转化为医疗保健提供者、政策制定者和社区团体，以改善临床护理并促进防止产前暴露于有害化学品的政策。我们的长期目标是开发早期识别有害接触的新技术，设计预防环境介导性疾病的新策略，与卫生保健专业人员和社区团体发展新的关系，传递有关环境污染物对早期发育影响的科学信息，并在这一重要的产前环境健康和研究领域激发职业选择和倡导。

A large and growing literature links exposure to chemicals during specific periods of fetal development with: adverse birth outcomes, such as preterm delivery and low birthweight; childhood illnesses, such as neurodevelopmental disorders and cancer; and later onset of adult disorders, such as diabetes and cardiovascular disease. In addition, large national biomonitoring studies are reporting nearly ubiquitous exposure to numerous environmental contaminants in the US population, raising the question of how exactly people are being exposed and what are the implications. Furthermore, studies of mid-gestation pregnancies confirm that the placenta does not act as a barrier to exogenous chemicals and also indicate that the fetus - at a time when it lacks detoxifying mechanisms - may experience higher levels of exposure than the mother. We propose to assemble a new, integrated, multidisciplinary group of researchers from the biological, clinical and epidemiologic sciences into the UCSF Pregnancy Exposures and Environmental Contaminants Formative Center. The theme of the PEEC Formative Center is to advance our understanding of how exposure to environmental chemicals affects early development using an innovative multidisciplinary approach that 1) integrates research on sources and exposures to environmental chemicals during pregnancy with basic biological research on how chemical exposures may disrupt early development and 2) translates these scientific findings to healthcare providers, policy makers and community groups in order to improve clinical care and promote policies that prevent prenatal exposures to harmful chemicals. Our long term goals are to develop novel techniques for early identification of harmful exposures, to devise novel strategies for the prevention of environmentally mediated diseases, to develop new relationships with health care professionals and community groups to transmit scientific information about the effect of environmental contaminants on early development, and to inspire career choice and advocacy in this important area of prenatal environmental health and research.