PRENATAL EXPOSURE TO MANGANESE AND ADHD-LIKE BEHAVIORS IN CHILDHOOD

描述（由研究者提供）：注意缺陷多动障碍（ADHD）的病因学尚不清楚，识别可改变的环境风险因素对于降低其发病率非常重要。锰（Mn）既是一种必需的营养素，也是一种潜在的神经毒物，一般人群通常会接触到。这项研究的主要目的是调查产前锰与使用新生儿行为评估量表（NBAS）的婴儿和学龄儿童中ADHD相关行为的关系（中位数=8岁）使用三种评估：（1）临床诊断的ADHD;（2）与ADHD相关的行为，使用Conners教师评定量表评估：和（3）与ADHD相关的行为，用正式的心理测量测试测量，包括神经行为评估系统2连续性能测试和韦氏儿童智力量表第三版的组成部分。我们还将研究锰和铅（Pb）对ADHD风险的潜在协同作用。该研究将在1993年至1998年间出生的788名婴儿的出生队列中进行，这些婴儿的母亲居住在马萨诸塞州新贝德福德受金属和多氯联苯污染的港口和超级基金地点附近。在存档的脐带血样品中测量Mn。将使用多变量回归估计相关性，控制广泛的协变量。这项拟议的研究是迄今为止美国最大的一项评估产前锰对儿童随后神经行为影响的研究，并将受益于使用一个充分表征的人群，该人群自出生以来已对其发育进行了纵向评估，并提供了大量关于儿童发育不良风险因素的信息。结果将提供重要的洞察锰的作用作为一个潜在的可补救的风险因素常见的行为障碍，如多动症。锰（Mn）是一种天然存在的金属，既是必需营养素，也是潜在的神经毒物。本研究将探讨产前锰与儿童神经行为发育，特别是ADHD相关行为之间的关系。我们的研究结果将提供重要的洞察锰作为潜在的可补救的风险因素，这种日益普遍和昂贵的儿童行为障碍的作用。

DESCRIPTION (provided by investigator): The etiology of Attention Deficit Hyperactivity Disorder (ADHD) is poorly understood and identification of modifiable environmental risk factors is important for reducing its incidence. Manganese (Mn) is both an essential nutrient and, at high levels, a potential neurotoxicant to which the general population is commonly exposed. The primary aim of the proposed research is to investigate the association of prenatal Mn with behaviors associated with ADHD among infants using the Neonatal Behavioral Assessment Scale (NBAS), and among school-aged children (median=8 years) using three assessments: (1) clinically diagnosed ADHD; (2) behaviors associated with ADHD assessed with the Conners' Rating Scale for Teachers: and (3) behaviors associated with ADHD measured with formal psychometric tests, including the Neurobehavioral Evaluation System 2 Continuous Performance Test, and components of the Wechsler Intelligence Scale for Children-Third Edition. We will also investigate potential synergism between Mn and lead (Pb) on risk for ADHD. The study will be conducted among a birth cohort of 788 infants born between 1993 and 1998 to mothers residing adjacent to a metal- and PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts. Mn is measured in archived cord blood samples. Associations will be estimated with multivariable regression, controlling for a wide range of covariates. The proposed study is the largest U.S. study to date to assess the effect of prenatal Mn on subsequent neurobehavior in children and will benefit from the use of a well characterized population whose development has been assessed longitudinally since birth and for whom a wealth of information on risk factors for adverse child development is available. Results will provide important insight into the role of Mn as a potentially remediable risk factor for common behavioral disorders such as ADHD. PUBLIC HEALTH RELEVANCE: Manganese (Mn) is a naturally occurring metal which is both an essential nutrient, and potential neurotoxicant. This study will investigate the association between prenatal Mn and childhood neurobehavioral development, particularly ADHD-related behavior. Our findings will provide important insight into the role of Mn as potentially remediable risk factor for this increasingly common and costly behavioral disorder of childhood.