PROTEOGENOMICS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这一核心的目的是为项目调查人员提供专家咨询、技术培训和最先进的仪器设备的资源，以便通过应用DNA微阵列分析、定量聚合酶链式反应和基于蛋白质的(蛋白质组学)方法来促进他们的研究工作。DNA微阵列分析组件允许研究人员使用DNA微阵列筛选技术，通过应用Affymetrix基因芯片筛选和先进的计算/统计分析方法进行全面的基因表达谱分析。蛋白质组学部分为研究人员提供技术援助和仪器资源，以使用传统的和尖端的基于蛋白质生物化学的技术，包括多重微珠阵列和表面等离子体技术来解决蛋白质功能问题。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this core is to provide project investigators with a resource for expert consultation, technical training, and state-of-the-art instrumentation to enable advancement of their research efforts through the application of DNA microarray analysis, qPCR and protein based ('proteomic') approaches. The DNA microarray analysis component permits investigators to use DNA microarray screening technology to perform comprehensive gene expression profiling through application of Affymetrix GeneChip screening and advanced computational/statistical analysis methods. The proteomics component provides investigators with technical assistance and instrumentation resources to use conventional and cutting edge protein biochemistry-based technologies including multiplex bead array and surface plasmon technology to address questions of protein function.