Training Program in Nutrition and Cancer

描述（由申请人提供）：本研究培训计划的目的是在跨学科的研究和教学环境中提供综合培训。该计划旨在为博士前学生和博士后研究员提供机会，以加强他们在癌症病因学和预防方面的研究培训和经验，重点是饮食因素对癌症发展和保护的作用。受训者将接受培训，了解遗传决定因素在改变饮食因素对癌症发展的影响方面的作用。学员将在各种研究环境中与经验丰富的导师直接合作，从实验室的基本机制研究，到人群的观察性研究，再到临床试验，以测试食物（或膳食剂）对癌症保护的有效性。该培训计划涉及癌症流行病学，营养学，癌症生物学，遗传和分子流行病学，生物统计学的核心课程，以及研究设计，实验室方法，人类和动物实验研究的教程。此外，受训人员将被要求通过完成专门针对个人需求的培训计划，在第二个领域接受跨学科培训。 该培训方案是流行病学和社区卫生司与营养研究生方案之间的一项联合努力。参与的教师导师是流行病学和/或营养研究生课程的积极成员，他们目前正在进行多项资助的研究，调查饮食或饮食成分在癌症发展和保护中的作用。鉴于缺乏这样的计划在上中西部地区的美国，这个培训计划是独特的适合和高度需要。 我们建议这项研究培训补助金将支持3名博士预科生和3名博士后研究员在第1年和4名博士预科生和4名博士后学员在每年2-5。根据最近的数据申请我们的流行病学和/或营养研究生课程，我们将期望有一个相对较大的潜在学员谁将申请到这个培训计划鉴于卓越的研究和教学参与教师导师和拟议的多学科培训方法。 培训计划的进展和成功将每年由一个指导NCI资助的培训计划的专家小组进行评估。在培训后的10年里，将密切跟踪和追踪学员的职业发展和研究活动。 相关性：该培训计划将培养新一代的研究人员，他们在流行病学和营养科学这两个主要学科中训练有素，对癌症生物学和遗传学有着深刻的理解。新一代的科学家将有能力对癌症进行多学科的病因学和预防研究，并大大提高我们对消除癌症造成的痛苦和死亡的认识，这是国家癌症研究所（NCI）提出的最终目标。

DESCRIPTION (provided by applicant): The purpose of this research training program is to provide integrated training in an interdisciplinary research and teaching setting. The program is directed toward providing opportunities for both predoctoral students and postdoctoral fellows to enhance their research training and experience in cancer etiology and prevention with an emphasis on the role of dietary factors on cancer development and protection. Trainees will be trained in understanding the role of genetically determined factors in modifying the effect of dietary factors on cancer development. Trainees will directly work with experienced mentors in a variety of research settings from the basic mechanistic studies in laboratory, to observational studies in populations, to clinical trials to test the effectiveness of food (or dietary agents) on cancer protection. The training program involves core courses in cancer epidemiology, nutrition, cancer biology, genetic and molecular epidemiology, biostatistics, and tutorials on research design, laboratory methods, and human and animal experimental studies. In addition, trainees will be required to have cross-disciplinary training in a second field by completion of a training program specifically tailored to the individual needs. This training program is a joint effort between the Division of Epidemiology and Community Health and the Nutrition Graduate Program. The participating faculty mentors are active members of the Epidemiology and/or Nutrition Graduate Programs who are currently conducting multiple funded studies investigating the role of diet or dietary constituents in cancer development and protection. Given the lack of such a program in the upper Midwest region of the United States, this training program is unique suited and highly needed. We propose this research training grant will support 3 predoctoral students and 3 postdoctoral fellows in year 1 and 4 predoctoral and 4 postdoctoral trainees in each of years 2-5. According to recent data on applicants to our Epidemiology and/or Nutrition Graduate Program, we will expect to have a relatively large pool of potential trainees who will apply to this training program given the excellence in research and teaching of participating faculty mentors and the proposed multidisciplinary training approach. The progress and success of the training program will be evaluated annually by a panel of experts in directing NCI-funded training programs. The career development and research activity of trainees will be closely followed up and tracked during the 10 years post-training. RELEVANCE: This training program will create a new generation of researchers superbly trained in two primary disciplines: epidemiology and nutritional science with deep understanding of cancer biology and genetics. This new generation of scientists will be competent to undertake multidisciplinary etiologic and preventive research on cancer and significantly advance our knowledge on Eliminating the Suffering and Death due to Cancer, the ultimate goal set forth by the National Cancer Institute (NCI).