TRAINING IN ORTHOPEDIC SKELETAL BIOLOGY

描述（由申请人提供）：这是一份综合的博士前和博士后培训支持申请，将把骨骼组织修复和再生机制和生物学的前沿临床策略与实验研究结合起来。该提案基于拉什大学医学中心解剖与细胞生物系的骨骼生物学项目，该项目与骨科外科（包括国内首屈一指的临床骨科小组之一以及一群杰出的基础科学家）合作。拉什大学其他两个临床科室（内科风湿病科和整形外科）的教员将作为导师或联合导师参与研究。该计划的目标是为对骨骼生物学多学科领域的学术事业感兴趣的博士生、博士后和医学生提供教育、培训和研究机会。该计划将强调骨骼修复和再生的机制，以指导培训骨科，风湿病学和颅面外科的基础生物学研究基础。招收研究生3名，博士后2名，短期研修生2名。除了传统的博士研究生和医学博士/博士研究生外，还将特别努力招收攻读医学博士/硕士学位的学生。虽然我们的医学博士/硕士项目相对较新，但所有参与的学生都走上了成为医学科学家的令人鼓舞的道路。我们认为这条赛道对对外科职业感兴趣的学生尤其重要，因为临床训练要求非常长。因此，强调医学博士/硕士学位（而不是医学博士/博士学位）仍然允许有意义的密集研究经验，但只增加了一年（而不是三年）的整个培训方案。在博士后层面，我们计划特别关注医学博士和医学博士/博士的招聘。短期研究培训生机制将被用作向仍在考虑攻读医学博士/硕士或医学博士/博士的医学生介绍研究的一种方式。我们正在采取这一策略来帮助增加骨科骨骼生物学领域的内科科学家的数量。相关性：这项拨款将帮助培训科学家改善受损骨骼和关节的愈合。目前的矫形手术是成功的，但我们希望通过更好地了解身体用于自我修复的潜在病理和机制来改善结果。最终，治疗将更多地依赖于身体自我更新的自然能力，而不是人工材料的使用。

DESCRIPTION (provided by applicant): This is an application for integrated pre- and post-doctoral training support that will bring together cutting edge clinical strategies with experimental investigations on the mechanisms and biology of skeletal tissue repair and regeneration. The proposal is based in the skeletal biology program centered in the Department of Anatomy & Cell Biology at Rush University Medical Center in partnership with the Department of Orthopedic Surgery (which includes one of the premier clinical orthopedic groups in the country as well as an outstanding group of basic scientists). Faculty from two other clinical departments at Rush (Section of Rheumatology from the Department of Internal Medicine and the Department of Plastics & Reconstructive Surgery) are expected to participate as mentors or co-mentors. The objective of the proposed program is to provide education, training and research opportunities to doctoral students, postdoctoral fellows and medical students interested in academic careers in the multi-disciplinary area of skeletal biology. The program will emphasize mechanisms of skeletal repair and regeneration in order to direct training to basic biological research foundations for orthopedics, rheumatology and craniofacial surgery. We are requesting support for 3 graduate students, 2 post-doctoral fellows and 2 short-term research trainees. In addition to traditional PhD students and MD/PhD students, a special effort will be made to recruit students seeking combined MD/MS degrees. Although our MD/MS program is relatively new, all of the students who have participated are on a very encouraging track of becoming physician-scientists. We think this track is particularly important for students interested in surgical careers because of the extremely long clinical training requirements. Thus, emphasis on the MD/MS (as opposed to the MD/PhD) still permits a meaningful intense research experience, but adds only one year (as opposed to three years) to the entire training regimen. At the post-doctoral level, we plan to pay special attention to the recruitment of MDs and MD/PhDs. The short-term research trainee mechanism will be used as a way to provide an introduction to research for medical students who are still considering the MD/MS or MD/PhD option. We are taking this strategy to help bolster the number of physician-scientists in orthopedic skeletal biology. Relevance: This grant will help train scientists to improve healing of damaged bone and joints. Current orthopedic procedures are successful, but we hope to improve outcomes through a better understanding of the underlying pathologies and mechanisms the body uses to repair itself. Eventually, treatments will rely more on the body's natural ability at self-renewal and less on the use of artificial materials.