Biology of Infectious Diseases Training Program

描述（由申请人提供）：这是UCSF传染病生物学培训计划的第二次竞争性更新修订申请，旨在培养在传染病基础科学研究方面富有成效的内科科学家。在美国，尽管抗生素、疫苗随处可见，公共卫生水平也很高，但传染病仍是第三大常见死因。在世界范围内，传染病是导致死亡的主要原因。新病原体的出现、旧病原体的重新出现、抗菌剂耐药性的增强以及全球化的压力打破了各种障碍，助长了传染病的传播。遏制和控制传染病传播的战略将越来越依赖于强有力的流行病学和基于人群的方法，以及应用基因组学、微生物发病机制和免疫学领域的发现所产生的基础研究进展。UCSF传染病生物学培训项目是根据美国传染病学会的指导方针和建议建立的，有两个培训项目，一个是基础研究项目，一个是临床研究项目。这两个轨道为获取和翻译研究工具、技能和经验以及培养科学创造力提供了结构框架，这对于成功的研究型职业至关重要。双轨结构也为跨学科的交流和互动提供了机会。该项目受益于完善的教学基础设施和指导研究项目的互动教师，提供丰富多样的深度和质量的培训环境。培训的重点是医学博士和医学博士研究生，但也接受博士博士后候选人。该计划仅存在了五年，在将受训者转变为独立的研究资金来源并使他们走上有前途的职业轨迹方面取得了相当大的成功。修订后的申请具有一个创新的计划，即招募未被充分代表的少数族裔学员加入该计划；作为前一版本的弱点，我们认为这一计划代表了修订后提案的主要优势。相关性：拟议的培训方案与公共卫生高度相关，其中一个主要关切是传染病的控制。我们将培训下一代的医学科学家，他们将负责公共卫生和制定战略，以遏制传染性病原体构成的威胁，他们将进行必要的研究，以确定新的病原体，以及那些将发现克服这些病原体的方法和疗法的科学家。

DESCRIPTION (provided by applicant): This is a second revised application for competitive renewal for the UCSF Biology of Infectious Diseases Training Program to train physician-scientists for productive careers in fundamental scientific investigations of infectious diseases. Infectious diseases are the third most common cause of death in the United States, despite widespread availability of antibiotics, vaccines, and high standards of public health. Worldwide, infectious diseases are the leading cause of death. Emergence of new pathogens, re-emergence of old ones, increasing resistance to antimicrobials, and pressures of globalization have broken down barriers and contributed to the spread of infectious diseases. Strategies to contain and control the spread of infectious diseases increasingly will rely on strong epidemiologic and population-based approaches and advances in basic research resulting from applications of discoveries in the fields of genomics, microbial pathogenesis, and immunology. The UCSF Biology of Infectious Diseases Training Program, which is modeled according to Infectious Diseases Society of America guidelines and recommendations, features two training tracks, a Basic Investigator Track and a Clinical Investigator Track. These two tracks provide the structural framework for acquisition and translation of research tools, skills, and experiences and for cultivating the scientific creativity that are essential for a successful research-oriented career. The two-track structure also affords the opportunity for interdisciplinary exchange and interactions. The program benefits from a well-established didactic infrastructure and an interactive faculty who direct research programs offering a rich and diversified training environment of exceptional depth and quality. Training is focused on MD and MD-PhD applicants, but PhD post-doctoral candidates are also accepted. In existence for only five years, the program has had considerable success in transitioning trainees to independent sources of research funding and starting them on promising career trajectories. This revised application features an innovative plan to recruit underrepresented minority trainees into the program; viewed as the weakness of the previous version, we believe this plan represents a major strength of the revised proposal. Relevance: The proposed training program is highly relevant to public health, a major concern of which is the control of infectious diseases. We will be training the next generation of medical scientists who will have responsibility for public health and devising strategies to contain the threats posed by infectious agents, scientists who will conduct the studies needed to identify new agents, and those who will discover approaches and therapies to overcome them.