Host-Microbe Interactions

描述(由申请者提供)：拟议的培训计划的主要目标是首先招聘有才华和高度上进的研究生，其次为他们提供一流的培训，为他们在学术研究领域的职业生涯做好准备，成为有竞争力的、独立的研究人员。该项目教师的研究兴趣涵盖了关于宿主-微生物相互作用的广泛问题和发病机制中的相关主题，这使得进入培训的学生有相当广泛的实验系统、方法和研究主题的选择。培训选项包括动物和人类系统，从而增强我们吸引和培训博士和医学博士/博士学生从事研究职业的能力。拟议的培训补助金的另一个优势是参与的教职员工的研究计划的质量。这项提案包括19名资金充足的项目教员，他们在许多当前感兴趣的领域做出了富有成效、及时和充满活力的研究努力。特别的优势领域是细菌、寄生虫和病毒致病的分子遗传学；寄生虫的细胞和免疫生物学；B细胞激活以及与T辅助细胞和淋巴因子的相互作用；粘膜免疫反应；宿主-病原体相互作用中的信号事件；各种免疫机制在抵抗传染病中的作用，包括由细菌、真菌、寄生虫和逆转录病毒引起的疾病，如艾滋病毒和小鼠艾滋病(MAIDES)病毒；免疫疗法和疫苗设计。这些领域是利用现代遗传学、免疫学、生物化学和分子生物学技术进行研究的。我们拥有出色的设施和资源来促进这些技术的应用，包括新的或翻新的实验室。这项提议还受益于现有强大的研究生课程，这些课程有助于获得博士学位。分子发病机制的培训跨越六个系，包括两个研究生项目-分子和细胞生物学以及实验和分子医学项目-前者包含大多数参与的教职员工和学生。与该组织一致的是，达特茅斯大学分子发病机制的研究生培训是一种跨学科的方法，由高度互动的环境培养，在这种环境中，学员定期在各种论坛上接触到从临床到基础科学研究的不同教师专业领域，包括一些高级课程、每周研讨会系列和期刊俱乐部，以及务虚会。

DESCRIPTION (provided by applicant): The primary goals of the proposed training program are first to recruit talented and highly-motivated graduate students and second to provide them with first-rate training that will prepare them for careers in academic research as competitive, independent investigators. The program faculty's research interests span a wide range of questions regarding host-microbe interactions and related topics in pathogenesis, which allows the entering trainee a considerable breadth of choice of experimental systems, approaches, and research topics. Training options include animal and human systems, thus enhancing our ability to attract and train Ph.D. and M.D./Ph.D. students for research careers. Another strength of the proposed training grant is the quality of the research programs of the participating faculty. This proposal includes 19 well-funded program faculty members who have productive, timely, and energetic research efforts in numerous areas of current interest. Particular areas of strength are molecular genetics of bacterial, parasitic, and viral pathogenesis; cellular and immunobiology of parasites; B cell activation and interaction with T helper cells and lymphokines; mucosal immune responses; signaling events in host-pathogen interactions; involvement of various immune mechanisms in resistance to infectious diseases including those caused by bacteria, fungi, parasites and retroviruses such as HIV and mouse AIDS (MAIDS) virus; immunotherapeutics and vaccine design. These areas are pursued using the full range of modern genetic, immunblogic, biochemical, and molecular biologic techniques. We have outstanding facilities and resources to facilitate the application of these techniques, including new or renovated laboratories. The proposal also benefits from the presence of strong existing graduate programs leading to the Ph.D. degree. Training in molecular pathogenesis spans six departments that encompass two graduate programs - Molecular and Cellular Biology and Program in Experimental and Molecular Medicine - with the former containing the majority of the participating faculty and students. Consistent with this organization, graduate training in molecular pathogenesis at Dartmouth is an interdisciplinary approach that is nurtured by a highly interactive environment in which the trainees are regularly exposed to diverse areas of faculty expertise, from clinical to basic science studies, in a variety of forums, including a number of advanced courses, weekly seminar series and journal clubs, and retreats.