VIRAL VECTOR CORE

病毒载体核心：Director-J。约翰斯顿 向量核心的主要目标是为DERC中心成员提供访问最先进技术的途径 临床前研究的载体技术。为了促进媒介的创建和生产， 专业工作人员将使用最先进的设施进行以下工作：1)生产病毒 来自腺相关病毒(AAV)、腺病毒和慢病毒的载体以及 生产用于基础研究的非病毒载体；2)与DERC调查人员合作 开发专门用于DERC成员的载体或重组病毒；3)开发 将优于前几代的基因转移载体；4)提交 将载体生产到生物测定核心以确定载体的数量、纯度和效力 制作；5)开发一个基于网络的数据库，使经社文中心成员能够请求 服务，监控病媒生产的状态，并访问由 他们的实验室。

VIRAL VECTOR CORE: Director-J. Johnston The main objective of the Vector Core is to provide DERC center members access to state-of-theart vector technology for preclinical studies. In order to facilitate vector creation and production, the professional staff, using a state-of-the-art facility, will carry out the following: 1) Production of viral vectors derived from adeno-associated viruses (AAV), adenoviruses, and lentiviruses as well as the production of non-viral vectors for use in basic research; 2) Work with DERC Investigators to develop vectors or recombinant viruses specifically of use to DERC members; 3) Development of gene transfer vectors that will be superior to those of previous generations; 4) Submission of the vectors produced to the Bioassay Core to determine the quantity, purity and potency of the vectors produced; 5) Development of a web-based database to enable DERC members to request services, monitor the status of vector production, and access historical data on vectors produced by their laboratory.