Intestinal Stem Cell Consortium Coordinating Center

描述（由申请人提供）：我们将在City of Hope建立肠道干细胞联盟协调中心（ISCC-CC）。ISC-CC将在Joyce C. Niland，信息科学主席。ISCC-CC的总体目标是支持肠道干细胞联盟（ISCC）建立高效和有效的程序，用于肠道干细胞的保存，分离和表征，同时开发和验证该细胞群体的特异性标志物。ISCC-CC将与NIDDK选择的5-7个不同研究项目的研究人员合作。ISCC-CC将优化整个ISCC项目的研究管理、协调、质量控制和信息管理。 具体目标是： 1.为ISCC的所有指导和小组委员会会议以及电话会议提供行政支持和监督; 2.为所有ISCC-CC研究项目提供共同的行政职能，协调ISCC-CC集中系统和流程最能服务的ISCC活动; 3.利用最先进的信息技术和强有力的安全/保密措施，建立和维护信息系统协调委员会的信息系统和信息管理程序; 4.通过ISCC资源的分配，如ISCs，以及ISCC成员之间的研究进展、方法、数据和信息的数据交换，促进转化研究;以及 5.支持ISCC实验和数据的设计、分析和质量保证，优化ISCs的生产和共享，开发和验证干细胞标志物。 公共卫生相关性：影响小肠的疾病代表了一系列不同的疾病，这些疾病可能导致受影响个体从腹泻到死亡的任何疾病。2004年，消化系统疾病导致美国约236，000人死亡，直接和间接费用近1，420亿美元。在这些报告的死亡中，有9836人部分归因于小肠疾病。了解小肠的生物学将有助于开发治疗肠道疾病的疗法。

DESCRIPTION (provided by applicant): We will establish the Intestinal Stem Cell Consortium Coordinating Center (ISCC-CC) at City of Hope. The ISC-CC will be under the direction of Dr. Joyce C. Niland, Chair of Information Sciences. The overall objective of the ISCC-CC is to support the Intestinal Stem Cell Consortium (ISCC) in establishing efficient and effective procedures for the preservation, isolation, and characterization of intestinal stem cells, while developing and validating specific markers for this population of cells. The ISCC-CC will do this by working with investigators from 5-7 different research projects chosen by NIDDK. The ISCC-CC will optimize study administration, coordination, quality control and information management across the ISCC projects. The specific aims are: 1. To provide administrative support and oversight to the ISCC for all Steering and Sub-Committee meetings and teleconference calls; 2. To serve the administrative functions common to all ISCC-CC research projects, coordinating ISCC activities that are best served by centralized ISCC-CC systems and processes; 3. To create and maintain the ISCC information systems and information management processes, using state-of-the-art information technology and robust security/confidentiality; 4. To promote translational research through distribution of ISCC resources, e.g. ISCs, and data exchange of research progress, methods, data, and information between members of the ISCC; and 5. To support the design, analysis and quality assurance of ISCC experiments and data, to optimize the production and sharing of ISCs and develop and validate stem cell markers. PUBLIC HEALTH RELEVANCE: Diseases affecting the small intestine represent a diverse collection of conditions that can cause anything from diarrhea to death in affected individuals. In 2004 digestive diseases were responsible for approximately 236,000 deaths in the United States and nearly $142 billion dollars in direct and indirect expenses. Of those reported deaths, 9836 were attributable, in part of whole, to conditions of the small intestine. Understanding the biology of the small intestine will aid in the development of therapies to treat intestinal diseases.