Supporting New Faculty Recruitment Through BioMedical Research Core Center

描述（由申请人提供）：明尼苏达大学肺，过敏，重症监护和睡眠（PACCS）部门一直在系统地招募更多的医生科学家专注于肺损伤和修复加入终身教职。我们的教师会见并确定了我们的教师在这一领域的研究兴趣概况显着差距-呼吸道感染。这一领域不仅在美国和世界范围内作为公共卫生问题非常重要，而且在明尼苏达大学也是一个具有杰出的多学科合作科学机会的领域。在PACCS部门内，在我们NIH资助的PI中，有7名教师具有肺部炎症和损伤方面的专业知识。此外，还有三个学术上强大的中心和计划与我们建议的招聘有关，提供了一个充满活力的研究环境，以促进科学成长和职业发展。传染病，微生物学和转化研究中心汇集了来自医学，儿科和微生物学系的教师，对微生物发病机理进行跨学科的转化研究。该中心为肺部科学和健康提供了一个家，为教师和学生从整个学术健康中心和较大的大学与肺部健康和疾病相关的利益。最后，明尼苏达大学有一个国际知名的囊性纤维化计划。虽然该计划在临床护理和临床试验活动方面表现突出，但基础研究部分却不那么强大。因此，PACCS部门的一个主要招聘目标领域是研究呼吸道感染的医生-科学家，特别是与囊性纤维化肺损伤相关的医生。我们建议的P30招募，布赖恩威廉姆斯医学博士，博士正在完成他的第四年肺，重症监护和CF奖学金在范德比尔特大学。他的研究重点是呼吸道感染中的宿主-病原体相互作用，特别是探索多胺前体胍丁胺的作用，这在假单胞菌感染和生物膜形成中很重要。他在Arnie Smith博士的指导下获得了微生物学博士学位，研究嗜血杆菌感染，他的博士后研究由Timothy Blackwell博士监督。威廉姆斯博士的研究与他对CF相关肺病的临床兴趣直接相关，使他的研究和临床项目能够融合。 Bryan Willliams医学博士，博士的招聘将为PACCS分部研究增加呼吸道感染专业知识的新维度，这将大大增强囊性纤维化中心计划的基础研究，并将为肺部科学与健康中心和传染病中心之间提供研究桥梁，微生物学转化研究。威廉姆斯博士的研究为理解和减少CF患者的假单胞菌感染带来了一种创新的方法。

DESCRIPTION (provided by applicant): The University of Minnesota Pulmonary, Allergy, Critical Care & Sleep (PACCS) Division has been systematically recruiting additional physician scientists focused on lung injury and repair to join the tenure track faculty. Our faculty met and identified a significant gap in our faculty research interest profile in this area - respiratory infections. This area is not only of great importance as a public health issue in the US and worldwide, it is also an area with outstanding multi-disciplinary, collaborative scientific opportunities at the University of Minnesota. Within the PACCS Division, among our NIH-funded PIs, there are 7 faculty with expertise in lung inflammation and injury. In addition, there are three academically strong Centers and programs pertinent to our proposed recruit, providing a dynamic research environment to promote scientific growth and career development. The Center for Infectious Disease, Microbiology & Translational Research brings together faculty from the Medicine, Pediatrics and Microbiology Departments in interdisciplinary translational research on microbial pathogenesis. The Center for Lung Science and Health provides a home for faculty and students from across the Academic Health Center and larger University with interests related to lung health and disease. Finally, the University of Minnesota has an internationally renowned Cystic Fibrosis program. While this program is outstanding in clinical care and clinical trials activity, the basic research component is less strong. Thus a major recruitment target area of the PACCS Division is for a physician-scientist with research focused on respiratory infections, particularly with relevance to lung injury in Cystic Fibrosis. Our proposed P30 recruit, Bryan Williams MD, PhD is completing his fourth year of Pulmonary, Critical Care & CF fellowship at Vanderbilt University. His research focus is on host-pathogen interactions in respiratory infections, specifically exploring the role of a polyamine precursor, agmatine, that is important in Pseudomonas infections and in biofilm formation. He obtained his Microbiology PhD under the mentorship of Dr. Arnie Smith studying Hemophilus infections and his post-doctoral fellowship research has been supervised by Dr. Timothy Blackwell. Dr Williams' research relates directly to his clinical interest in CF-related lung dise disease, enabling convergence of his research and clinical program. The recruitment of Bryan Willliams MD, PhD will add the new dimension of expertise in respiratory infections to the PACCS Divisional research It will greatly augment basic research in the Cystic Fibrosis Center program and will provide a research bridge between the Center for Lung Science and Health and the Center for Infectious Disease, Microbiology Translational Research. Dr Williams's research brings an innovative approach to understanding and decreasing Pseudomonas infection in CF patients.