THE EFFECTS OF EXERCISE ON CORONARY BLOOD FLOW

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在运动期间，交感神经系统调节血压、心率、通气和外周血管收缩。 在肌肉需求增加的情况下，需要进行循环调节，以保持重要器官的适当灌注。 由于技术限制，交感神经对人类冠状动脉血流动力学反应的控制是不可能的。 最近，无创多普勒超声技术使这种评估成为可能。 因此，本研究的目的是评估运动期间的冠状动脉血流量。 还将评估年龄、性别（月经周期）和心力衰竭的影响。 最后，还将在心脏和肾脏移植患者中完成评估，以区分冠状动脉血管收缩和肌源性自动调节反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During exercise the sympathetic system adjusts blood pressure, heart rate, ventilation and peripheral vasoconstriction. Circulatory adjustments are required to maintain proper profusion to vital organs during increased demands of muscles. Due to technical limitations sympathetic control over coronal hemodynamic responses in humans has not been possible. The noninvasive Doppler ultrasound technique has recently made this assessment possible. Thus, the aim of this study is to assess coronary blood flow during exercise. Modifying effects of age, gender (menstrual cycle) and heart failure will also be assessed. Finally, assessment will also be completed in heart and kidney transplant patients to discriminate between coronary vasoconstriction and myogenic autoregulation response.