ADRENAL ANDROGEN PRODUCTION IN NORMAL AND OBESE GIRLS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 青春期女孩的黄体酮和睾丸素在清晨升高，在青春期早期增加最为明显。此外，与正常体重的青春期早期女孩相比，肥胖的青春期早期女孩的黄体酮和睾丸素都会增加。我们将研究正常和肥胖女孩所有青春期阶段的肾上腺对这些荷尔蒙变化的贡献。我们将用单剂量地塞米松急性抑制肾上腺功能，然后用ACTH刺激肾上腺功能。这一结果将使我们了解整个青春期肾上腺对孕酮和睾酮产生的贡献，以及正常体重和肥胖女孩的肾上腺孕酮和睾酮产生的不同。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Early morning increases in progesterone and testosterone have been observed in adolescent girls, increases which are most marked in early puberty. Additionally, progesterone and testosterone are increased in obese early pubertal girls compared to normal weight early pubertal girls. We will examine the adrenal contribution to these hormonal changes in normal and obese girls of all pubertal stages. We will acutely suppress adrenal gland function with a single dose of dexamethasone and subsequently stimulate adrenal gland function with ACTH. The results will allow us to understand the adrenal contribution to progesterone and testosterone production throughout puberty and how adrenal progesterone and testosterone production differs in normal weight and obese girls.