SENSORY ION CHANNELS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 色氨酸家族的非选择性阳离子通道代表了人体生理学中最重要的离子通道之一(Montell，2005a；Montell，2005b)，并构成了一类主要的药物靶点。温塞尔的研究包括TRPV1(95 KDa)，它是痛苦的热的受体，也感受辣椒中的活性成分，辣椒素，TRPV2，另一个热传感器，以及TRPY1，酵母液泡的一种离子通道，对渗透胁迫做出反应，将钙释放到细胞质中。温塞尔和他的同事使用低温电子显微镜和单粒子分析来确定色氨酸家族的离子通道结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The TRP family of non-selective cation channels represents one of the most important classes of ion channels for human physiology (Montell, 2005a; Montell, 2005b), and constitutes a major class of drug targets. Those studied by Wensel included TRPV1 (95 kDa), the receptor for painful heat that also senses the active ingredi-ent in hot chili peppers, capsaicin, TRPV2, another heat sensor, and TRPY1, an ion channel of the yeast vacuole that releases calcium into the cytoplasm in response to osmotic stress. Wensel and colleagues have used cryo-EM and single particle analysis to determine structures of ion channels of the TRP family.