SIMULTANEOUS MEASUREMENTS OF ADC AND PO2

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 超极化氦-3磁共振成像（HP 3 He MRI）已被广泛用于 在区域基础上对肺结构和功能进行定量评估。肺泡大小气道 在小空间尺度上的形态可以用HP 3 He MR表观扩散来阐明 ADC成像。还开发了用于测量 肺氧分压（PAO 2）和肺氧摄取（ODR）。以前在这方面的工作导致了一个 基于多元回归的单次采集技术用于PAO 2的同时测量 ODR。该技术现已扩展到同时测量PAO 2、ODR和3 He ADC。这种方法在人类中具有特殊的意义，因为它允许相关的测量， 肺功能和结构。此外，它允许所有三个量在一个测量 单次屏气，而不是两次呼吸，这既减少了扫描时间， 所需的HP 3 He气体量。 这些因素有助于重复测量肺 氧合和气体扩散在大规模人体试验和未来的临床应用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hyperpolarized helium-3 magnetic resonance imaging (HP 3He MRI) has been extensively used for quantitative assessment of lung structure and function on a regional basis. Alveolar size airway morphology at the small spatial scales can be elucidated using HP 3He MR apparent diffusion coefficient (ADC) imaging. Specific techniques have also been developed for measurement of pulmonary oxygen tension (PAO2) and uptake (ODR). Previous work in this area led to a multiple-regression-based single acquisition technique for simultaneous measurement of PAO2 and ODR. This technique is now expanded for simultaneous measurement of PAO2, ODR and 3He ADC. This approach is of special significance in human by allowing for correlated measurements of lung function and structure. Moreover, it allows for all three quantities to be measured in one single breath-hold, rather than in two breaths, which decreases both the scan time and the required amount of HP 3He gas. These factors facilitate repeated measurements of lung oxygenation and gas diffusion in large-scale human trials and future clinical applications.