MACROMOLECULAR STRUCTURE DETERMINATION - GENERAL USERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这一分项目由一组项目组成，这些项目要么没有摘要，要么总使用量不到赠款美元的0.1%，由调查人员实施，每个项目都消耗光束时间收集X射线衍射数据，以解决三维晶体结构问题。调查人员包括在人员名单中，他们是没有与任何其他分项目联系在一起的人。使用总额不到赠款美元0.1%的调查人员/次级项目包括： 斯蒂芬·布莱克洛·特里布尔斯 XrCC4/LigaseIV的Murray Junop MAD数据收集 约翰·亨特MDR ABC运输商 Alex Bohm大T抗原起始结合结构域+I位DNA靶点 七鳃鳗可变淋巴细胞受体的Roy Mariuzza结构分析 蛋白质-蛋白质界面亲和力成熟的结构基础 泛素连接酶的BINHO结构 Leemor Joshua-Tor红细胞结合抗原175区(EBA-175)II区结构测定 凯瑟琳·莱蒙·基尔频道 果糖1，6-二磷酸酶抑制剂FBP1a复合体的Evan Kantrowitz结构 白介素5受体与白介素5的复合体 钙调神经磷酸酶的总超甲调节域 天冬氨酸氨基转移酶突变体T态的Evan Kantrowitz结构 未连接并与MHC分子结合的T细胞受体的Kannan Natarajan结构 梭状芽胞杆菌Quentin Vicens Group I核酶 Heldwein HSV-1 GB Y179S突变株，酸性条件 马歇尔-米勒细胞毒素相关基因A与微管亲和力调节蛋白2共结晶 乔纳森·戈德堡对SEC 13/SEC 31复合体的结构测定 HotDog-Fod硫代酯酶的Karen Allen结构及其作用机制 钾和氯通道的Roderick Mackinnon结构 克里斯托弗·希尔20s：Blm3 ETLI根瘤菌自身诱导因子-2受体同系物的结构研究 Heldwein HSV-1 GB W174R突变株，酸性条件 四膜虫Quentin Vicens Group I核酶P4-P6结构域 Elias Lolis CXCL12(基质细胞衍生因子1-α)与肝素的络合物 Evan Kantrowitz结构ATCase被二硫键锁定在R态 红民李抗核糖体抗体的结构和功能 内质网氨基肽酶ERAP1的劳伦斯-斯特恩结构 海尔德韦恩Ekaterina Heldwein HSV-1 GB Y179S突变株，基本条件 钙调神经磷酸酶的总超甲钙调素结合域 卡罗琳·科恩重肌球蛋白 Miguel Garcia-Diaz转录因子A，线粒体 延斯·伯克托夫特DNA设计师水晶 细菌蛋白的Sivaraman Jayaraman结构研究 帕特里夏·豪厄尔铝酸盐生物合成 史蒂文·布鲁纳肠杆菌素生物合成酶Entf硫代化-硫酯酶比多胺 GspD、GSPC结构域与纳米体的Marissa Yanez三元络合物 Marianna Teplova CUG结合蛋白1 RNA沉默中的元天结构研究 Evette Radisky人中胰蛋白酶S195A-与APPI的复合体-晶屏条件#33 锥虫转录因子TZB的David Wah结构 卡南·纳塔拉扬 威廉·洛瑟游离蛋氨酸-(R)-亚砜还原酶1 50S核糖体亚基底物类似物的Thomas Steitz结构研究 TCRE8与野生型和突变型黑色素瘤抗原结合的Roy Mariuzza晶体结构 伊利NK受体KLRG1与粘附素复合体 含Fe++和CuB++的伊鲁肌红蛋白 埃里克·梅里休粘着斑激酶 Leemor Joshua-Tor鉴定参与RNA诱导转录基因沉默的蛋白质复合体 布莱恩·埃肯罗斯人血清转铁蛋白 谷氨酸肌醇糖基转移酶的Lee Tremblay结构研究 珍黄2‘-Seme修饰的寡核苷酸 宋智俊对染色质的修饰 La自身抗原对Alexander Serganov RNA的识别作用 Leemor Joshua-Tor染色域 Aneel Aggarwal人Rev1跨损伤DNA聚合酶

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This subproject consists of a group of projects for which either abstracts were not available, or the total use was less than 0.1% of grant dollars, carried out by investigators who each consumed beamtime for the collection of x-ray diffraction data for 3-dimensional crystal structure solving. The investigators are included in the list of personnel, and they are the ones not identified with any other subproject. The investigators/subprojects for which their total use was less than 0.1% of grant dollars include the following: Stephen Blacklow Tribbles Murray Junop MAD data collection of Xrcc4/ligaseIV John Hunt MDR ABC transporters Alex Bohm large t antigen origin binding domain + site I DNA target Roy Mariuzza Structural Analysis of Lamprey Variable Lymphocyte Receptors Roy Mariuzza Structural Basis for Affinity Maturation of a Protein-Protein Interface Bing Hao Structure of the ubiquitin ligase Leemor Joshua-Tor Erythrocyte binding antigen 175 (EBA-175) region II structure determination Kathryn Lemmon Kir channel Evan Kantrowitz Structure of Inhibitor complexes of fructose 1,6 bisphosphatase - Inhibitor FBP1A Patrick Loll Interleukin-5 receptor in complex with interleukin-5 Zongchao Jia Regulatory domain of calcineurin Evan Kantrowitz Structure of Aspartate Trancarbamoylase mutant in the T state Kannan Natarajan Structures of T cell receptors, unliganded and in complex with MHC molecules Quentin Vicens Group I ribozymes from Clostridiae Ekaterina Heldwein HSV-1 gB Y179S mutant, acidic conditions Marshall Miller Cytotoxin-associated gene A co-crystallized with microttubule affinity-regulating kinase 2 Jonathan Goldberg Structure determination of the Sec 13/ Sec 31 complex Karen Allen Structure and Mechanism of Hotdog-Fod Thioesterases Roderick Mackinnon Structure of Potassium and Chloride Channels Christopher Hill 20S:Blm3 Stephen Miller Structural studies of the Rhizobium etli autoinducer-2 receptor homologue Ekaterina Heldwein HSV-1 gB W174R mutant, acidic conditions Quentin Vicens Group I ribozyme P4-P6 domain from Tetrahymena Elias Lolis CXCL12 (Stromal Cell-derived factor 1-alpha) in complex with heparin Evan Kantrowitz Structure ATCase locked in R state by disulfide bonds Hongmin Li Anti-ribosomal antibody structure and function Lawrence Stern Structure of the endoplasmic reticulum aminopeptidase ERAP1 Ekaterina Heldwein HSV-1 gB Y179S mutant, basic conditions Zongchao Jia Calmodulin binding domain of calcineurin Carolyn Cohen heavy meromyosin Miguel Garcia-Diaz Transcription Factor A, mitochondrial Jens Birktoft DNA designer Crystals Sivaraman Jayaraman Structural Studies on bacterial proteins Patricia Howell Algnate biosynthesis Steven Bruner enterobactin biosynthetase EntF Thiolation-Thioesterase bidomain Marissa Yanez Ternary complex of domains from GspD, GspC and a nanobody Marianna Teplova CUG-Binding Protein 1 Yuan Tian Structural study in RNA silencing Evette Radisky human mesotrypsin S195A - complex with APPI - crystal screen condition #33 David Wah Structure of the trypansome transcription factor TZB Kannan Natarajan William Lowther Free methionine-(R)-sulfoxide reductase 1 Thomas Steitz Structural Studies of the 50S ribosomal subunit with substrate analogues Roy Mariuzza Crystal structures of TCR E8 complexed with both wild-type and mutant melanoma antigens presented by HLA-DR1 Yili Li NK receptor KLRG1 and Cadherin complex Yi Lu Myoglobin with Fe++ and CuB++ Eric Merithew Focal Adhesion Kinase Leemor Joshua-Tor Characterization of protein complexes involved in RNA induced transcriptional gene silencing Brian Eckenroth Human Serum Transferrins Lee Tremblay Structural Studies of GlcNAc-Insositol glycosyltransferase. Zhen Huang 2'-SeMe-modified oligonucleotides Ji-Joon Song Chromatin Modification Alexander Serganov RNA recognition by La autoantigen Leemor Joshua-Tor chromodomains Aneel Aggarwal Human Rev1 translesion DNA polymerase