DIAGNOSTIC MRI AND SPECTROSCOPY OF THE OVARIES AT 3 TESLA

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 由于临床需要改善卵巢癌的成像，我们已经开始了妇科肿瘤（Levi唐斯）和CMRR（帕特里克博兰）之间的合作。我们的目的是开发和评估现代“功能性”MR方法，包括光谱，扩散成像和动态对比增强成像，以改善卵巢癌的筛查，诊断和治疗监测。与其他癌症部位相比，在卵巢癌中这种MR方法的发展相对较少。 我们的初步计划是在整个临床环境中进行探索性研究，包括化疗前后正常卵巢、良性卵巢病变和恶性病变的受试者。最初提出的项目包括在2年内（约每周1次）扫描分布在这些组中的100名受试者。该提案的细节作为单独的附件列入。该项目目前没有资金，但已提交给几个地方供资来源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driven by the clinical need for improved imaging of ovarian cancer, we have begun a collaboration between Gynecologic Oncology (Levi Downs) and the CMRR (Patrick Bolan). Our intent is to develop and evaluate modern "functional" MR methods including spectroscopy, diffusion imaging, and dynamic contrast-enhanced imaging for improved screening, diagnosis, and treatment monitoring of ovarian cancers. Compared to other cancer sites, there has been relatively little development of such MR methods in ovarian cancer. Our initial plan is to perform an exploratory study across the spectrum of the clinical setting, including subjects with normal ovaries, benign ovarian lesions, and malignant lesions both pre and post chemotherapy treatment. The initial project proposed includes scanning 100 subjects over a 2-year period (approximately 1/week) distributed across these groups. Details of this proposal are included as a separate attachment. This project is currently unfunded but has been submitted to several local funding sources.