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A study of the interrelationships between drug release and polymer biodegradation of novel drug-polymer conjugates (DPCs)

A study of the interrelationships between drug release and polymer biodegradation of novel drug-polymer conjugates (DPCs)
新型药物-聚合物缀合物(DPC)的药物释放与聚合物生物降解之间相互关系的研究
批准号:
LP140100284
负责人:
Prof Thomas Davis
金额:
$31.64万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Linkage Projects
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-10-03 至 2017-06-30

项目摘要

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中文摘要
翻译
本项目涉及新型聚氨酯基药物-聚合物缀合物的综合研究。将使用模块化方法对各种成分进行仔细检查,以组装药物共轭装置,从而产生不同的聚合物生物降解特性,药物释放率和物理性质。该项目旨在提供有关关键要素之间相互关系的关键知识,以便每个要素都可以精确定制,以满足特定生物位点和药物的特定要求。最终,本研究旨在生产适用于治疗疾病的新型药物载体聚合物装置。
英文摘要
This project involves a comprehensive investigation of novel polyurethane based drug-polymer conjugates. A variety of components will be scrutinised using a modular approach for assembling the drug conjugated devices, resulting in different polymer biodegradation characteristics, drug release rates and physical properties. The project aims to provide key knowledge about the inter-relationships between the key elements so that each can be precisely tailored to meet the specific requirements of a particular biological site and drug. Ultimately, this study intends to lead to the production of new drug-carrier polymer devices suitable for the treatment of illnesses and diseases.
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Complex nano-systems for highly selective imaging and targeting of cells
  • 批准号:
    DP160104196
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $30.92万
  • 财政年份:
    2016
  • 负责人:
    Prof Thomas Davis
  • 依托单位:
Macromolecular design for bio-imaging and targeted delivery
  • 批准号:
    FL140100052
  • 项目类别:
    Australian Laureate Fellowships
  • 资助金额:
    $167.24万
  • 财政年份:
    2014
  • 负责人:
    Prof Thomas Davis
  • 依托单位:
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology
  • 批准号:
    CE140100036
  • 项目类别:
    ARC Centres of Excellence
  • 资助金额:
    $1878.81万
  • 财政年份:
    2014
  • 负责人:
    Prof Thomas Davis
  • 依托单位:
Design of multimodal polymeric nanoparticles as targeted carriers for the co-delivery of therapeutic molecules
  • 批准号:
    DP130100107
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $25.58万
  • 财政年份:
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  • 负责人:
    Prof Thomas Davis
  • 依托单位:
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