MULTIMODAL IMAGING OF THE SENSORY GATING DEFICIT IN SCHIZOPHRENIA

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 多线研究一致记录了精神分裂症（SP）患者的感觉处理缺陷。一个这样的缺陷是差的感觉门控，其中与健康正常志愿者（HNV）相比，SP中的两个快速呈现的刺激中的第二个的电生理反应增加。这种效应通常以门控比的形式报告，门控比比较第一（S1）和第二（S2）刺激的响应幅度（S2/S1*100）。差的感觉门控被表征为选择性注意和/或记忆痕迹形成的缺陷，并且是通常在SP中观察到的认知和随后的社会功能障碍的有用生物标志物。尽管动物和侵入性人类研究一直涉及听觉皮层、前额皮质和海马介导感觉门控反应，在这些结构中的局部激活在非侵入性成像模式中并不总是被报道。此外，这种缺陷主要是使用电生理技术，如脑电图（EEG）和脑磁图（MEG）记录的。迄今为止，还没有一个单一的功能磁共振成像（FMRI）的研究，其特点是血流动力学标记的门控缺陷，精神分裂症使用传统的门控范例。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple lines of research have consistently documented sensory processing deficits in patients with schizophrenia (SP). One such deficit is poor sensory gating, in which there is an increased electrophysiological response for the second of two rapidly presented stimuli in SP compared to healthy normal volunteers (HNV). This effect is typically reported in terms of a gating ratio comparing the amplitude of the response for both the first (S1) and second (S2) stimulus (S2/S1*100). Poor sensory gating has been characterized as both a deficit in selective attention and/or in the formation of memory traces, and is a useful bio-marker of the cognitive and subsequent social dysfunction that is typically observed in SP. Although animal and invasive human studies have consistently implicated the auditory cortex, prefrontal cortex and hippocampus in mediating the sensory gating response, localized activation in these structures has not always been reported during non-invasive imaging modalities. Moreover, this deficit has been primarily been documented using electrophysiological techniques such as electroencephalography (EEG) and magnetoencephalography (MEG). To date, there has not been a single functional magnetic resonance imaging (FMRI) study that has characterized hemodynamic markers of the gating deficit in schizophrenia using the traditional gating paradigm.