INNOVATIVE NURSERY-REARING FOR IMPROVING RHESUS MACAQUES AS BIOMEDICAL MODELS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 国家研究资源中心（NCRR）的一个主要目标是在NCRR资助的灵长类中心维持成功的无特定病原体（SPF）猕猴繁殖计划，这些猕猴不含常见的逆转录病毒，这些病毒可以干扰艾滋病实验和其他类型的研究。目前，SPF群体通过在没有非SPF母亲的情况下抚养婴儿来建立。因此，建立和维持这些SPF群体的长期成功的关键是制定有效的策略，以最大限度地减少由于其母亲的社会剥夺而出现的行为病理学，并导致社会能力的发展。拟议的研究将导致发展的互动代理同行养育设计，将提供一个附件的数字，婴儿以及响应应急关系的附件数字（代理）和同行。在早期发育过程中提供这些功能应该会使托儿所养育的婴儿比没有这些功能的托儿所养育的婴儿具有更多正常的社交，运动，知觉和认知技能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major goal of the National Center for Research Resources (NCRR) is to maintain successful breeding programs at NCRR-funded primate centers for specific-pathogen-free (SPF) macaque monkeys that are free of common retroviruses that can interfere with AIDS experiments and other types of research. SPF colonies are currently established by raising infants without their non-SPF mothers. Therefore, key to the long-term success of establishing and maintaining these SPF colonies is to develop efficacious strategies for raising infant monkeys in ways which minimize the emergence of behavioral pathologies due to social deprivation of their mothers and which will lead to the development of social competence. The proposed study will lead to the development of an interactive surrogate-peer rearing design that will provide both an attachment figure to the infant as well as response-contingency relationships with the attachment figure (surrogate) and peers. Providing these features during early development should result in nursery-reared infants with more normal social, motor, perceptual and cognitive skills than nursery-reared infants without these features.