Clinical Core

临床核心中心是该中心的业务中心。它是收集满足中心范围目标以及每个研究模块的具体目标所必需的数据不可或缺的一部分。临床核心还对核心家庭(N=775个家庭)的所有成员进行精神诊断评估，这些家庭包括先证者父亲、其配偶以及有亲生子女和继子女的家庭。继父母也会接受诊断性评估。此外，该中心还为儿童进行医学和牙科检查，并向每个家庭成员执行研究方案，包括收集生物标本(血液、唾液、皮肤、尿液)，以便及时分发到各个实验室。临床核心确保符合匹兹堡大学IRB的要求， HIPPA和NIH法规。除了主要负责该中心科学活动的业务支持外，该中心的教职员工也完整地参与了实证研究。因此，最近的出版物集中在不同的主题上，包括口腔健康在SUD发展、自杀、性行为和STD、死亡率以及健康和精神合并症中的作用。

The Clinical Core is the operational hub of the Center. It is integral to collecting the data necessary for satisfying centerwide aims as well as the specific aims of each research module. The Clinical Core also conducts the psychiatric diagnostic evaluations of all members of the nuclear family (N= 775 families) consisting of the proband father, his spouse, and has biological and stepchildren. Step-parents are also diagnostically evaluated. In addition, this Core performs medical and dental examinations of the children and administers the research protocols to each family member, including collection of biological specimens (blood, saliva, skin, urine) for timely distribution to various laboratories. The Clinical Core ensures compliance with the University of Pittsburgh IRB, HIPPA, and NIH regulations. While primarily responsible for operational support of the Center's scientific activities, faculty in this Core are also integrally involved in empirical research. Accordingly, recent publications have focused on diverse topics, including the role of orodental health on SUD development, suicidality, sexual behavior and STD's, mortality, and health and psychiatric comorbidity.